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EC number: 216-721-0
CAS number: 1653-19-6
Although an investigation of skin corrosivity and irritation in which rabbits were treated topically with 2,3 dichloro-1,3 butadiene in a 50/50 mixture with methylene chloride did not indicate the substance to be corrosive or an irritant, the study did not provide sufficient information to determine the potential dermal irritation elicited by skin contact. On the basis of limited information on the ocular irritancy of 2,3 dichloro-1,3 butadiene provided in the OECD SIDS Initial Assessment Report, 2,3 dichloro-1,3 butadiene can be regarded as a potential eye irritant. There are no substantive data from guideline compliant studies or other evidence to indicate that DCBD is a potential skin or respiratory irritant.
In a non-standard study of irritation and corrosivity in which six
albino rabbits received topical applications (on skin clipped free of
hair on their backs) of 2,3 dichloro-1,3 butadiene /methylene chloride
(50/50) no reactions indicative of dermal corrosion or irritation were
reported. The study did not provide sufficient information to determine
the potential dermal irritation elicited by skin contact with 2,3
Two in vivo studies on the potential ocular irritancy of DCBD have been
evaluated by the OECD as part of ICCA HPV initiative (SIDS Initial
Assessment Report 2006). Khechumov et al., (1972) reported that
inflammation and purulent conjunctivitis were observed in rabbits after
drops of 2,3 dichloro-1,3 butadiene (unspecified isomer of unknown
purity) were placed in their conjunctival sac. The conjunctivitis was
reversible within 21-22 days. Marhold (1986) reported that the
application of 500 mg 2,3 dichloro-1,3 butadiene (unknown purity) into
the eyes of rabbits for 24 hours lead to a mild eye irritation (Marhold,
1986). In a precautionary approach, on the basis of limited information
on the ocular irritancy of DCBD provided in the OECD SIDS Initial
Assessment Report, 2,3 dichloro-1,3 butadiene can be regarded as a
potential eye irritant.
Respiratory irritation, characterised by degeneration of the nasal
olfactory epithelium, has been reported in rats following sub-chronic
whole body inhalation exposures to 2,3 dichloro-1,3 butadiene at
concentrations up to 50 ppm. These effects have not however been
confirmed by acute or single administration guideline-compliant studies.
On the basis of limited information on the ocular irritancy provided in
the OECD SIDS Initial Assessment Report, 2,3 dichloro-1,3 butadiene can
be regarded as an eye irritant. GHS classification is proposed as: Eye
Irrit. 2; H319: Causes serious eye irritation (67/548/EEC self
classification: Xi; R36 Irritant; Irritating to eyes)
In limited studies, 2,3 dichloro-1,3 butadiene administered with
methylene chloride (50:50) was not found to be dermal corrosive and no
indications of skin irritation were observed. Data from unreliable
studies suggest, that 2,3 -dichloro-1,3 -butadiene is irritating to the
skin of rabbits. Therefore a classification as Xi, R 38, GHS: skin
Irrit. 2, H315: causes skin irritation is proposed.
Although indications of respiratory tract irritation have been reported
in a sub-chronic, whole body inhalation exposure study in rats, this has
not been confirmed by acute or single administration studies conducted
according to the relevant guidelines for respiratory irritation.
Although no clear evidence for respiratory irritation is obvious, a
respiratory tract irritation cannot be excluded and therefore a
classification as Xi, R 37, GHS: STOT Single Exp. 3, H335: May cause
respiratory irritation is proposed.
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