Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 216-721-0
CAS number: 1653-19-6
No additional information provided.
Six male albino ChR-CD rats were exposed to atmospheres containing the
test material for a single 4 -hour period. All surviving animals were
weighed and observed daily for 14 days post-exposure. Selected animals
were sacrificed at 1, 2, 7 and 14 days post-exposure for
histopathological examination. The LC50 was 2.08 mg/L. The test
substance caused no obvious clinical signs during exposure, but severe
weight losses and rapid respiration were observed during the early
recovery period. Deaths, both early and delayed, were preceded only by
severe weight losses. Histopathologically, the test substance produced
necrosis in the bronchiolar epithelium, liver, kidney, and testes. The
survivors demonstrated partial recovery from these injuries at the end
of the 14 -day recovery period.
2,3 -Dichlorobutadiene (LRT-218) should be considered moderately toxic
by inhalation exposure and 2 -chloro-1, 3 -butadiene is classified as a
slightly toxic compound by inhalation exposure (LRT-220). Under REACH
Classification the material is harmful by inhalation, R20.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
За да гарантираме, че се възползвате максимално от функциите на нашия уебсайт, сме въвели „бисквитки“.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again