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EC number: -
CAS number: -
The in vivo genotoxic potential of EXP0700332 was evaluated in a
micronucleus test in bone marrow erythrocytes of young, male and female
rats following a 0 h and 24 h oral dosing and 48 h sampling regimen.
A Dose Range Finding study was undertaken to establish a suitable dose
range for the main micronucleus experiment. Based on the findings of the
Dose Range Finder, the maximum recommended dose of 2000 mg/kg/day was
judged to be a suitable dose level for the micronucleus test.
In the micronucleus test, groups of rats were dosed at 0 h and 24 h via
the oral route with EXP0700332 at the maximum recommended dose level,
2000 mg/kg/day. Bone marrow samples were taken 24 h after the final
dose. Two control groups of rats were also dosed orally with either the
vehicle, peanut oil (10 mL/kg/day), or the positive control agent,
cyclophosphamide (50 mg/kg/day). An untreated control group was also
included. The experimental schedule for the control groups followed that
of the test item treated rats.
No micronucleus induction was detected in bone marrow erythrocytes of
rats dosed with EXP0700332.
Animals treated with the vehicle alone showed normal background levels
of micronuclei, while animals dosed with cyclophosphamide responded with
substantial increases in the numbers of bone marrow micronuclei.
In conclusion, EXP0700332 did not induce micronuclei in bone marrow
cells when tested to the maximum recommended dose of 2000 mg/kg/day in
male and female Sprague Dawley (CD) rats using a 0 h and 24 h oral
dosing and 48 h sampling regimen.
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