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EC number: -
CAS number: -
The purpose of this study is to evaluate the adverse effects of
EXP0700332 following dermal exposure for 24 hours. Male and female
Sprague-Dawley rats were housed in groups up to five animals of the same
sex, then separated into single housing and clipped before dosing. The
dose of the test item was calculated on the day of dosing. 2000 mg/kg of
test item was applied topically to each animal on the clipped dorsal
area and spread as evenly as possible. The dosed area was then covered
with a gauze patch which was secured with semi-occlusive tape and
non-irritating occlusive tape, wrapped around the trunk. The females
were dosed 5 days after the males. After 24 hours, the patches and tape
were removed and the dosing sites were delinated and cleaned with
mineral oil. The animals were observed for 14 days thereafter for signs
of reaction. The body weight of the rats were recorded weekly and all
animals were subjected to necropsy examinations on Day 15. There were no
clinical signs of reaction to treatment, no unscheduled deaths, no
abnormal findings in the necropsy and the body weights of all animals
were considered acceptable for rats of this strain and age.
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