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EC number: -
CAS number: -
This test guideline was desgined to assess the effects of prolonged
exposure to chemicals on the growth of juvenile fish.
Juvenile fish in exponential growth phase were placed, after being
weighed, in the test chambers and were exposed to a range of sublethal
concentrations of the test substance dissolved in water, preferably
under semi-static conditions, for 28 days. At the end of the test, the
fish were weighed again and the effects on growth rates were analysed
using a regression model; the lowest observed effect loading rate
(LOELR) and the no observed effect concentration loading rate (NOELR)
Due to the complexity and low solubility of the mixture, the dissolved
test substance was below the limit of detection with the analytical
method, therefore the test result was based on a nominal loading rate.
The 'pseudo' specific growth rate (r3) of 10 mg/L, 18 mg/L, 32 mg/L, 56
mg/L and 100 mg/L loading rate WAF were compared with the blank control.
The results showed that the 28-day NOELR was 100 mg/L loading rate WAF
and the 20-day LOELR was more than 100 mg/L loading rate WAF based on
the nominal loading rate.
The aim of this study was to evaluate the Prolonged Toxicity of
EXP0700332 over a 14 -day test period. Zebra fish (Brachydanio rerio)
were exposed to aqueous test media containing the test item under
defined conditions. Recorded effects were threshold levels of lethality
and other observed effects and the NOEL for the test fish.
Due to the low water solubility and complex mixture of EXP0700332, the
dissolved test substance was below the detection limit of the analytical
method and, therefore, the results were based on nominal loading rates
Under the conditions of the test, the 14d threshold level of lethal
effect of test substance was greater than 102 mg/L loading rate WAF
based on nominal loading rate for Zebra fish (Brachydanio rerio). The
14d Lowest Observed Effect Loading Rate (LOEL) was more than 102 mg/L
loading rate WAF based on nominal loading rate. The 14d No Observed
Effect Loading Rate (NOEL) was 102 mg/L loading rate WAF based on
nominal loading rate.
14 Day Fish Toxicity Study
The study was conducted in accordance with GLP and the OECD 204
guideline. A limit test was performed at 102 mg/L loading rate WAF; the
lowest observed effect loading rate (LOELR) was more than 102 mg/L and
the no observed effect loading rate (NOELR) was 102 mg/L loading rate
WAF based on nominal loading rates.
Juvenile Growth Test
The study was conducted in accordance with GLP and the OECD 215
guideline. One blank control and five test concentrations of 10 mg/L, 18
mg/L, 32 mg/L, 56 mg/L and 100 mg/L loading rate WAFs were prepared. The
LOELR was more than 100 mg/L and the NOELR was 100 mg/L loading rate WAF
based on nominal loading rates.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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