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Physical & Chemical properties

Dissociation constant

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Endpoint:
dissociation constant
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Study period:
24 Mar 97- 11 May 97
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Restriction due to the fact that the study was conducted on read-across substance.
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 112 (Dissociation Constants in Water)
Principles of method if other than guideline:
Exceptions

1.This test method is appropriate for relatively pure substances. The test substance is a mixture therefore the results can only be considered an estimate.

2. A nonspecific analytical method, total organic carbon analysis was used to quantitate the test substance concentration in aqueous solution. The test substance was analyzed for percent carbon; this value and the results of TOC analysis of the aqueous solutions were used to calculate the test substance concentration in water.

GLP compliance:
yes
Dissociating properties:
no
Conclusions:
The test substance was determined to have no observable dissociation. 
Executive summary:

The study was conducted to determine the dissociation constant of the test material. The test substance was equilibrated in water and the water soluble fraction was then titrated with a standard base. The average concentration of four replicates of test substance in water was 1.50 x 10-6 mole/Liter. The test substance titration curve for each of the four replicates was indistinguishable from the blank. The test substance was determined to have no observable dissociation. The result on the analogue material was considered to be appropriate for the Registration material.

Endpoint:
dissociation constant
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Reason / purpose:
read-across source
Dissociating properties:
no

Description of key information

A GLP study conducted in accordance with the OECD 112 guideline, dissociation constant- no observable dissociation.
Justification for selection - only one study available.

Key value for chemical safety assessment

Additional information

A GLP study conducted in accordance with the OECD 112 guideline, reported that the test substance was determined to have no observable dissociation. The result on the analogue material was considered to be appropriate for the Registration material.