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Diss Factsheets

Environmental fate & pathways

Endpoint summary

Administrative data

Description of key information

Stability: Hydrolysis

Testing was not carried out according to Method C7 of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 111 of the OECD Guidelines for Testing of Chemicals, 13 April 2004 for the following reasons:

1. The test material was determined, to have a very low water solubility value of 0.0068 mg/l.            

2. As the hydrolysis guidelines require an initial solution concentration of less than half the water solubility, the test concentration would need to be even lower than this. On top of that, the guidelines also require the test material to be analytically measureable at 10% of the initial test concentration, further increasing the sensitivity that an analytical method would need to have. Test material concentrations, even after being extracted to concentrate the samples, would likely to be less than the limit of quantification.          

3. At the low concentration that would be required for the hydrolysis test, it would possibly be difficult to get near 100% recovery of test material from the aqueous samples, as seen in the recoveries performed for the water solubility. Loss of test material may be due to factors like adsorption to glassware. If sample concentrations got even lower, then recovery may reduce even further. The main functional groups in the test material are imides and an amide. Neither of these functional groups are normally susceptible to rapid hydrolysis under environmentally relevant conditions, but both are known to hydrolyse slowly nevertheless.  

Biodegradation: in water screening test

Where no surfactant was present the test material attained 67% degradation after 42 days (63 % degradation after 24 days). In the presence of the surfactant, the test material attained 72% degradation after 42 days. The OECD guideline criteria for classification of a chemical as readily biodegradable are as follows: 1) percent biodegradation must reach 60% within 28 days, and 2) the 60% degradation must be attained within 10 days of exceeding 10% biodegradation.

Under the strict terms and conditions of OECD Guideline No 301B the test material was considered to be rapidly biodegradable but it failed to satisfy the 10-Day window validation criterion.

Bioaccumulation: aquatic/sediment

The BCF of a test substance in test fish were as follow: High concentration level (0.2 mg/L) - A= BCFSS 56 (49-75*1), B= BCFSS < 87 (<60-87*2), C=BCFSS < 39 (<7-39*2) , D=BCFSS < 39 (3-39*2) and Low concentration level (0.02 mg/L) - A=BCFSS < 90 (<59-90*2), B=BCF < 667 (<623-<667*3), C=BCFSS < 64 (<62-<64*2), D=BCFSS < 33 (<31-<33*2).

Transport and distribution: Absorption/desorption

During testing it was observed that these hydrocarbon structures did not elute from a cyanopropyl solid phase HPLC column during the 45 minute run time. The adsorption coefficient of duplicate determinations of EXP0700332 test item was therefore determined to be as follows:

Log10 Koc of EXP0700332 >10.04 (retention time greater than 45 minutes run time

Koc of EXP0700332 > 1.10 x 10^10

Alternatively, the adsorption coefficient may be expressed as being greater than that of 4,4’-DDT, the latest eluting reference standard used. Since 4,4’-DDT has a theoretical adsorption coefficient of 5.63, it may be stated that for EXP0700332:

Log10 Koc >5.63

Koc >4.27 x 105

Additional information