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EC number: 200-835-2
CAS number: 75-05-8
One 15.0 mg/kg/day dosage group rabbit died on day 23 of gestation. At
necropsy, this rabbit had an umbilical hernia which had increased in
size during gestation and resulted in intestinal strangulation. This
death was not considered agent-related.
In a guideline (US EPA) and GLP study conducted by Argus Research Labs
(1984), oral (gavage) administration of aqueous solutions of
Acetonitrile (HPLV grade) to pregnant rabbits at dosages of 2.0, 15.0
and 30.0 mg/kg/day on days 6 through 18 of gestation was not a unique
hazard to the conceptus. Embryo/fetal lethality was observed only at a
maternally lethal dosage. Administration of these dosages to the dams
was not demonstrated to adversely affect the surviving fetuses, that is,
it did not result in retarded fetal growth or an increased incidence in
grossly observed external, soft tissue or skeletal malformations among
the fetuses. Based on these findings, the following NOAELs are
established for acetonitrile in the pregnant rabbit:
Maternal toxicity - 15 mg/kg/day
Fetotoxicity - 15 mg/kg/day
Teratogenicity - 30 mg/kg/day
Gastrointestinal symptoms observed in the rabbits that died are
considered to be a significant confounder in determining the
contribution from systemic chemical toxicity in this study.
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