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EC number: 200-835-2
CAS number: 75-05-8
Expert review and IOEL method
Reliable animal data indicate that acetonitrile is not a skin irritant,
is not acutely toxic by the dermal route, and is not a skin sensitizer.
Local effects are therefore unlikely. However a STEL of 60 ppm (102
mg/m3) is set UK HSE EH40/2005 Workplace exposure limits, 2nd Edition
2011. This may be reflective of early US ACGIH published values for a
STEL and is reasonably assumed to be protective of workers for short
The IOEL TWA converted to mg/kg dose over 8 h, breathing 10 m3, then
adjusted for 50% dermal absorption
A NOAEC in a chronic mouse study is used to calculate a modified dose
descriptor. In the chronic mouse study, exposure was for six hours a day
for five days a week. To convert this to 24 hour exposure for the
general popluation, the NOAEC needs to be corrected by a factor of 0.25
(6/24) and 0.714 (5/7).
The modified dose descriptor is therefore 336 mg/m^3 * 0.25 * 0.714,
which is 60 mg/m^3
Not required as taken from human volunteer study (4 h exposure)
NOAEC from chronic mouse inhaltion exposure study, converted to
equivalent rat exposure level for 24 h over 7 days per week.
The mouse 200 ppm NOAEC (6 h per day, 5 days per week) was converted to
a continuous exposure. This was multiplied by 1.15 m3/kg bw. This was
then divided by 7, to convert from the mouse to human.
No uses which expose the genral population to acetonitrile are supported.
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