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Environmental fate & pathways

Hydrolysis

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Endpoint:
hydrolysis
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Remarks:
Widely recognized data source. Cited in the EU RAR.
Principles of method if other than guideline:
No information available. Handbook source
GLP compliance:
not specified
Remarks:
Handbook source
Transformation products:
not measured
pH:
7
Temp.:
25 °C
DT50:
> 150 000 yr
Type:
not specified
Remarks on result:
other: hydrolysis rate constant = 5.8 x 10 -3 M-1 hour -1

pH; Rate constant; Half-life(est); Reference

7; 5.8 x 10-3/Mhr; >150,000 yr; Ellington et al. 1988*

9; 5.8 x 10-3/Mhr; 1364 yr; Ellington et al. 1988*

9; 2.1 - 3.5 x 10+6/Msec; >600 yr; Anbar & Neta, 1967*; Dorfman & Adams, 1973*

* cited in Howard, 1993.

The photooxidation half-life for acetonitrile in water, based on rate data for hydroxyl radicals in aqueous solution has also been estimated to be 314 -12559 years (Howard et al. 1991).

It has been stated that hydrolysis is unimportant, to the aquatic fate of acetonitrile, at the pH ranges normal for natural water (Ellington et al. 1988). The half-life for acetonitrile in water has been estimated to be >150,000 years based on a hydrolysis rate constant at pH 7 and 25 deg C of 5.8 x 10 -3 M-1 hour -1 (Howard, 1991).

Executive summary:

Hydrolysis is considered unimportant to the aquatic fate of acetonitrile, at the pH ranges normal for natural water (Ellington et al. 1988). The half-life for acetonitrile in water has been estimated to be >150,000 years based on a hydrolysis rate constant at pH 7 and 25 deg C of 5.8 x 10-3 /Mhr (Howard, 1991). As cited in the EU RAR.

Endpoint:
hydrolysis
Type of information:
calculation (if not (Q)SAR)
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature
Remarks:
Limited information available. Not widely recognized data sources.
Principles of method if other than guideline:
No information available. Secondary sources.
GLP compliance:
not specified
Remarks on result:
other: Hydrolysis is considered unimportant to the aquatic fate of acetonitrile, at the pH ranges normal for natural water.
Executive summary:

Hydrolysis is considered unimportant to the aquatic fate of acetonitrile, at the pH ranges normal for natural water.

Description of key information

Hydrolysis is not expected to be an important aquatic fate process for acetonitrile.  Acetonitrile is readily biodegradable.

Key value for chemical safety assessment

Half-life for hydrolysis:
150 000 yr
at the temperature of:
25 °C

Additional information

Hydrolysis is considered to be unimportant to the aquatic fate of acetonitrile, at the pH ranges normal for natural water (Ellington et al. 1988). The half-life for acetonitrile in water has been estimated to be >150,000 years based on a hydrolysis rate constant at pH 7 and 25 deg C of 5.8 x 10-3 Mhr (Howard, 1991).