Registration Dossier

Environmental fate & pathways

Endpoint summary

Administrative data

Description of key information

Additional information

No experimental data on bioaccumulation are available for acetonitrile. Based on low Kow values and high water solubility very low bioaccumulation potential is expected.

A bioconcentration factor for fish of 0.3 was calculated by Howard, 1993 using the log Pow = -0.34 value of Leo, 1971 and regression equations defined in Lyman et al (1982). This bioconcentration factor is in agreement with other calculated values which are in the range of 0.3-0.4 (EPA; 1991). An estimated BCF of 3 was calculated for acetonitrile by HSDB, 2009 using a log Kow of -0.34 (Hansch, 1995) and a regression-derived equation (Meylan, 1999). US EPA BCFWIN software (v2.17) generated an estimated BCF of 3.162 for acetonitrile based on the experimental log Kow of -0.34.

Regardless of the specific QSAR equation applied for these calculations the information consistently indicates a lack of bioaccumulation potential for acetonitrile in the environment.