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Toxicological information

Acute Toxicity: other routes

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Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Basic data given which meets scientific principles

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1959

Materials and methods

Principles of method if other than guideline:
Acute intraperitoneal toxicity
GLP compliance:
no
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): Acetonitrile
- Source: Union Carbide Chemicals Company

Test animals

Species:
mouse
Sex:
male

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
other: 10% acetonitrile in saline
Doses:
Single Dose

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LD50
Effect level:
0.25 other: g/kg
Mortality:
see table below

Any other information on results incl. tables

Summary of Response of Animals to Single Doses of Acetonitrile.

 Date  Route  Sex  Weight (g) Range  1ml = xgm  LD50 and range
 7/24/56  I.P. M  20 -28  0.1 in saline 0.25 (0.17 to 0.37) g/kg 

Applicant's summary and conclusion

Executive summary:

Pozzani et al (1959) reported acute ip LD50 values in male mice of 0.25 g/kg.