Registration Dossier
Registration Dossier
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EC number: 200-835-2 | CAS number: 75-05-8
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1959
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 959
Materials and methods
- Principles of method if other than guideline:
- Acute intraperitoneal toxicity
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- Acetonitrile
- EC Number:
- 200-835-2
- EC Name:
- Acetonitrile
- Cas Number:
- 75-05-8
- Molecular formula:
- C2H3N
- IUPAC Name:
- acetonitrile
- Details on test material:
- - Name of test material (as cited in study report): Acetonitrile
- Source: Union Carbide Chemicals Company
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): Acetonitrile
- Source: Union Carbide Chemicals Company
Test animals
- Species:
- mouse
- Sex:
- male
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- other: 10% acetonitrile in saline
- Doses:
- Single Dose
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 0.25 other: g/kg
- Mortality:
- see table below
Any other information on results incl. tables
Summary of Response of Animals to Single Doses of Acetonitrile.
| Date | Route | Sex | Weight (g) Range | 1ml = xgm | LD50 and range |
| 7/24/56 | I.P. | M | 20 -28 | 0.1 in saline | 0.25 (0.17 to 0.37) g/kg |
Applicant's summary and conclusion
- Executive summary:
Pozzani et al (1959) reported acute ip LD50 values in male mice of 0.25 g/kg.
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