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EC number: 200-835-2
CAS number: 75-05-8
The sensitivity of the test system was clearly demonstrated by the
marked increases in the frequencies of micronucleated polychromatic
erythrocytes induced by the positive control substance,
cyclophosphamide, at the expected times after dosing. Reductions in the
percentage of polychromatic erythrocytes were observed in the peripheral
blood of cyclophosphamide treated animals. This is a response which is
expected from a known cytotoxic drug.
In a guideline (OECD 474) and GLP study, Acetonitrile did not produce
significantly increased frequencies of micronucleated polychromatic
erythrocytes in the bone marrow or peripheral blood of mice following a
single maximum tolerated dose by intraperitoneal injection (100 mg/kg in
males; 125 mg/kg in females).
Comparison of the percentage of polychromatic erythrocytes showed
statistically significant increases, compared to the vehicle control
values, in the bone marrow of acetonitrile treated males at the 18 hour
sampling time and small increases, compared to the 0 hour control
values, in the peripheral blood of males at 48 and 72 hour sampling
times and in females at the 72 hour sampling time. These increases
suggest that the bone marrow has been subjected to stress at maximally
tolerated doses of acetonitrile.
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