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EC number: 200-835-2
CAS number: 75-05-8
Fisher SW (1984) reported no evidence of irritation or mortality (21
days) in earthworms treated with acetonitrile by topical application.
Acetonitrile was a solvent control used in this study. Doses of 1 -4 ul
were applied topically to worms weighing 4 -5 g. This corresponds to
doses in the range of 156 mg/kg to 780 mg/kg.
to the Integrated Testing Strategy for assessing the effects on
terrestrial organisms (Guidance on Information Requirements and Chemical
Safety Assessment, Chapter 7c End Point Specific Guidance, table 7.11.2)
if there is no indication for high absorption (i.e. logKow<5) and there
is no indication that the substance is very toxic (acute EC50>1mg/l) and
the PEC/PNEC<1 (where the PNEC is based on the equilibrium partitioning
method) then no toxicity testing is required. The
chemical safety assessment indicates this to be the case. On the basis
of this assessment, testing of soil organisms is not justified.
Based on the use pattern for this substance, direct and indirect
exposure of birds is unlikely. There is also a sufficient mammalian
dataset on this substance to allow reliable extrapolation to predict
toxicity to avian species if required.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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