Registration Dossier
Registration Dossier
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EC number: 695-022-6 | CAS number: 473278-76-1
Endpoint summary
Administrative data
Description of key information
Additional information
Studies investigating the terrestrial toxicity of tefuryltrione, are available for terrestrial invertebrates and soil microorganisms.
For the assessment of the terrestrial toxicity of tefuryltrione, data on toxicity to earthworms are particularly relevant due to their exposure via different uptake routes (i.e. exposure via soil pore water, ingestion of soil material). The short-term toxicity of the test substance to earthworms (Eisenia fetida) was investigated after 14-day exposure according to OECD guideline 207. The no-observed-effect-concentration (NOEC) with no mortality, no intoxication symptoms and no significant weight decrease compared to the control was ≥1000 mg test item/kg dry artificial soil.
The potential effects of tefuryltrione on nitrogen and carbon transformation of soil microorganisms was investigated using natural soil from an uncultivated site. The studies were performed according to OECD 216 (nitrogen transformation) and 217 (carbon transformation) under GLP conditions. In the study on carbon transformation no inhibition was recorded after 28 d. Thus, the EC10 and NOEC (28 d) were derived to be >4.00 mg/kg soil dw and ≥4.00 mg/kg soil dw, respectively. In the study on nitrogen transformation no inhibition was recorded after 56 days. Thus, the EC10 and NOEC (56 d) were derived to be >4.00 mg/kg soil dw and ≥4.00 mg/kg soil dw, respectively.
Moreover studies on the toxicity of tefuryltrione towards bees and birds are available. The oral toxicity of tefuryltrione to Apis mellifera was assessed (OECD 213) and a 72h LD50 of >95.78 μg substance per bee was determined. The contact toxicity of tefuryltrione to Apis mellifera, was investigated according to OECD 214. The substance was found to have a 72 h contact LD50 of >100 μg substance per bee.
The acute oral and short-term dietary toxicity of tefuryltrione was assessed in the Bobwhite quail (Colinus virginianus, OECD 223 & 205), the Japanese quail (Coturnix coturnix japonica, OECD 223), and Mallard duck (Anas platyrhynchos, OECD 205). Tefuryltrione was of low acute oral and short-term dietary toxicity to Bobwhite quail, Japanese quail and Mallard duck since the acute oral LD50 was >2000 mg/kg body weight in all studies. Moreover, the dietary LC50 was >3980 mg/kg feed for Bobwhite quail and >4213 mg/kg feed for Mallard duck, indicating low short-term toxicity. Beside one premature death, mortalities were observed at 2000 mg a.i./kg bw in the acute oral test with Japanese quail. Therefore, the non-lethal dose (NLD) was at 1734 mg a.i./kg bw.
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