Registration Dossier
Registration Dossier
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EC number: 695-022-6 | CAS number: 473278-76-1
Endpoint summary
Administrative data
Description of key information
Not Readily Biodegradable (28 d, OECD 301 F, activated sludge, WWTP for domestic sewage)
Aerobic biodegradation in sediment (OECD 308): DT50 in freshwater sediment at 20 °C: 6.3 - 24.2 days (13.4 - 51.4 days, recalculated to 12 °C) in the water phase; 20.8 - 35.1 (44.2 - 74.5 days, recalculated to 12 °C) in the total system
Aerobic Biodegradation in soil (Japan MAFF Test Guideline, 12-Nousan-No. 8147 Part 2-5-2):
DT50: 12.3 – 18.3 days at 25 °C (40.9 – 60.9 days, recalculated to 12 °C)
Aerobic Biodegradation in soil (OECD 307): DT50: 2.7 - 14.7 days at 20.3 °C, (5.9 – 32.1 days, recalculated to 12 °C)
Anaerobic Biodegradation in soil (OECD 307): DT50: > 1000 days at 20 °C
Additional information
Screening test on ready biodegradability
One GLP guideline study is available, which assessed the "Ready Biodegradability" of the test substance according to OECD guideline 301 F using activated sludge as inoculum. The initial test substance concentration was 100 mg/L, equivalent to 1.698 mg O2/mg ThOD. The test was conducted under aerobic conditions in the dark. The degradation rate was determined by following the oxygen consumption during the test period of 28 d.
The toxicity control showed no toxic effects on bacteria at the tested concentration. Results showed 4% degradation after 7 and 14 d, 6% after 21 d and 4% after 28 d. Therefore, the test substance is considered to be not readily biodegradable.
Aerobic biodegradation in sediment:
In a laboratory study, the route and rate of degradation of radiolabeled tefuryltrione was studied in two water/sediment systems under aerobic conditions. After 101 days, 0.7 and 1.0% of the applied radioactivity were mineralized to 14CO2. The determined half-lives in the water phase of the two systems were 24.2 and 6.3 days respectively (51.4 and 13.4 days, recalculated to 12 °C) and 35.1 and 20.8 (74.5 and 44.2 days, recalculated to 12 °C) in the total system.
Aerobic biodegradation in soil
The substance was degraded in soil under aerobic conditions in the dark in two laboratory studies. The calculated half-lives ranged between 2.7 and 18.3 days under the chosen test conditions, which correspond to temperature corrected DT50 values of 5.9 – 60.9 at 12°C (average environmental temperature in Europe). Formation of carbon dioxide was observed and ranged from 11.5 to 63.2% of the applied radioactivity during the aerobic incubation phase (120 days).
Anaerobic biodegradation in soil
The substance was not significantly degraded in soil under anaerobic conditions in the dark in the laboratory. The calculated half-lives under anaerobic conditions were > 1000 days.
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