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EC number: 202-681-1 | CAS number: 98-56-6
No significant positive reactions were observed in the skin/eye irritation on rabbit for the test substance.
Application on right flank (undiluted product)
24 hs after Application
48 hs after Application
72 hs after Application
96 hs after Application
Application on left flank (diluted product)
The test item was applied to the skin of the flank of 6 rabbits, through occlusive coverage. The right flank was treated with the undiluted product, while the left flank was treated with the 10% dilution of the product in sesame oil. The exposure time was 24 hours; the observation period was up to 72 hs. The irritation index was calculated based on erythema and oedema scores after 24 and 72 hours and it was found to be 1.9 for the undiluted product and 0.4 for the dilution. It is concluded that the test item is not irritating nor corrosive to skin.
The test item was instilled into the right eye of 6 rabbits, while the left eye served as control. 0.1 mL of undiluted product was instilled in the eye and washed after 72 hs. The observation period was up to 72 hs. Fluorescein was instilled after 48 hours and 72 hours to assess the scores. The irritation index was calculated based on effects on cornea, iris and conjunctiva after 1, 7, 24, 48 and 72 hours. The maximum score was 2 and it was observed after 7 hours. The effect was fully reversible after 24 hours. Therefore, the product is classified as not irritant to eyes.
Even if the presented studies are quite old, the whole data base is deemed to be sufficient to satisfy the data requirements for the tonnage band 100 -1000 t/a, as information on all the route of exposure are available, showing an overall low irritating potential of PCBTF to the test animals. The test species are in agreement with those indicated in the most recent test guidelines and therefore are relevant and adequate for the classification and the CSA.
The substance is not classified as irritant or corrosive for skin or eye as no effects were observed during the irritation/corrosion test.
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