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Toxicological information

Basic toxicokinetics

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Administrative data

Endpoint:
basic toxicokinetics in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Literature data, non-GLP

Data source

Reference
Reference Type:
publication
Title:
Application of molecular encapsulation for toxicology studies: toxicokinetics of p-chloro-alfa, alfa, alfa-trifluorotoluene in alfa-cyclodextrin or corn oil vehicles in male F334 rats.
Author:
Yuan, J., Jameson, C.W., Goehl, T.J., Collins, B,J., Purdie, W., Judd, L.
Year:
1991
Bibliographic source:
Toxicol. Appl. Pharmacol., 11, 107-115

Materials and methods

GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
rat
Strain:
Fischer 344
Sex:
male

Administration / exposure

Route of administration:
intravenous
Vehicle:
other: Tween 80 aquaous solution
Duration and frequency of treatment / exposure:
single injection in the tail vein
Doses / concentrations
Remarks:
Doses / Concentrations:
4.7 mg/kg bw
No. of animals per sex per dose:
2

Results and discussion

Main ADME resultsopen allclose all
Type:
distribution
Results:
very rapid
Type:
excretion
Results:
half-life = 20 hours

Toxicokinetic / pharmacokinetic studies

Toxicokinetic parameters
Toxicokinetic parameters:
half-life 1st: 20 h

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information): no bioaccumulation potential based on study results
The elimination of the test item from the blood after intravenous injection followed a triexponential equation with very rapid distribution in the tissues and a biological elimination half-life of about 20 hours.
Executive summary:

The toxicokinetics of p-chlorobenzotrifluride were studied in 2 male F344 rats following single intravenous administration of a tween 80 aqueous solution. The elimination of the test item from the blood after intravenous injection followed a triexponential equation with very rapid distribution in the tissues and a biological elimination half-life of about 20 hours.