Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 202-681-1 | CAS number: 98-56-6
NOEL and NOEC values are available from animal studies after repeated oral and inhalatory exposure. The lowest available oral NOEL is a 90-d value of 10 mg/kg bw/day and the lowest available inhalation 90-d NOEC is 51 mg/m³. No information on dermal effects of subchronic exposure is available.
Fischer 344 rats, 5 to 6 weeks age, were dosed orally by gavage each day for 3 months with corn oil solutions containing PCBTF. The doses, administered on an equal volume basis, were 0, 10, 40, 150 or 500 mg/kg body weight. Fifteen animals of each sex were included in each group. One low dose male and two high dose males died during the study. There were no treatment related physical or behavioral changes noted in any of the treated or control animals. Effects in this study were: elevated levels of blood urea nitrogen, total birilubin and alkaline phosphatase; induction of hepatic p-nitroanisole O-demethylase activity, increased liver and kidney weights, tubular degeneration in the kidneys and centrilobular hyperthrophy in the liver. Males were more sensitive to the effects of PCBTF than females. Compound induced changes were dose-related and were more pronounced at doses of 150 and 500 mg/kg. The lowest dose employed, 10 mg/kg, was tolerated for 90 days without significant toxicity in the rat.
In a literature study the effects of repeated exposure of rats to PCBTF via inhalation for 13 weeks were assessed. 10 Sprague Dawley rats/sex/dose were exposed to 10, 51, or 252 ppm of the test item for 6 hours/day, 5 days/week for 13 weeks. No PCTB-related effects were observed either during exposures or weekly clinical evaluations; no changes observed in body weight gain or measured hematological and clinical chemistry parameters; increase (11%) in relative liver weights in both sexes at highest dose tested correlated with centrilobular hypertrophy. NOEL (hepatocyte hypertrophy) = 51 ppm
The oral NOEL after 90-d exposure of 10 mg/kg bw/day has the same value of the oral NOEL after 14 and 28 days that was found in two literature studies that are here provided as supporting data. These results supports the conclusion that PCBTF does not accumulate in the body. The selected inhalation NOEC was obtained after 3 months and had a value of 51 mg/m³ for
6 h/day, 5days/week; this fits quite well with the supporting study NOEC of 5.5 mg/m³ obtained in a 4 months study where the exposure was 24 hours daily. No local effect was observed after the prolonged inhalation exposure.
Despite the low quality of the single data, the overall data base is considered relevant and reliable given the coherence of the results.
The substance is not classified for subchronic toxicity based on the results of repeated dose oral and inhalation studies showing that the threshold for classification was not reached.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Close Do not show this message again