Registration Dossier
Registration Dossier
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EC number: 457-670-6 | CAS number: 157859-20-6
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (sensitising)
- Additional information:
The skin sensitisation potential of the substance in the CBA/Ca strain mouse following topical application to the dorsal surface of the ear was tested.
The skin sensitising test described above meet the requirements of OECD Test Guideline 429 (LLNA) and is assigned to be reliability 1 data according to the scoring system of Klimisch et al (Klimisch et al., 1997). This ranking was deemed appropriate because the study was conducted the GLP certified laboratory and was in compliance with agreed protocols, with no or minor deviations from standard test guidelines and/or minor methodological deficiencies, which do not affect the quality of relevant results.
Migrated from Short description of key information:
The skin sensitisation potential of the substance in the CBA/Ca strain mouse following topical application to the dorsal surface of the ear was tested. The test methodology complies OECD TG 429 (LLNA). The results showed the dose-dependent positive reaction in the test condition.
Respiratory sensitisation
Endpoint conclusion
- Additional information:
There are no information available to assess sensitisation potential of the substance in the respiratory tract.
Migrated from Short description of key information:
There are no information available to assess sensitisation potential of the substance in the respiratory tract.
Justification for classification or non-classification
The test material was considered to be a sensitiser under the conditions of the test, based on the skin sensitising test (LLNA). The test material is classified as R43 May cause sensitisation by skin contact under Council Directive 67/548/EEC and Category 1 H317: May cause an allergic skin reaction under under Regulation (EC) No 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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