Registration Dossier
Registration Dossier
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 457-670-6 | CAS number: 157859-20-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Description of key information
No other studies available.
Effect on fertility: via oral route
- Dose descriptor:
- NOAEL
- 750 mg/kg bw/day
Additional information
As a result of the reproduction / developmental screening study, the treatment-related effects were observed. However, due to the lack of evidence of adverse effects for these observations, it is reasonable to derive the NOAEL in reproductive and developmental toxicity for triisopropylsilyl acrylate is 750 mg/kg/day in the test condition. It is not possible to derive the separate NOAEL for fertility and developmental/teratogenicity due to the limitation of the study design.
The methodology of the test meets the requirements of OECD Test Guideline 421 and is assigned to be reliability 1 data according to the scoring system of Klimisch et al (Klimisch et al.,1997). This ranking was deemed appropriate because the study was conducted the GLP certified laboratory and was in compliance with agreed protocols, with no or minor deviations from standard test guidelines and/or minor methodological deficiencies, which do not affect the quality of relevant results.
Short description of key information:
An screening test (OECD TG 421) was conducted to assess reproduction / developmental toxicity for the substance. The oral administration of triisopropylsilyl acrylate to rats by gavage, at dose levels of 750, 150 and 30 mg/kg/day, resulted in treatment-related effects in litters (reduced litter weights, reduced mean bodyweight gains and litter size of offspring) at 750 mg/kg/day, therefore, the ‘No Observed Effect Level’ (NOEL) was considered to be 150 mg/kg/day for reproductive toxicity. No other treatment-related effects were observed neither parental animals or offspring.
Effects on developmental toxicity
Description of key information
An screening test (OECD TG 421) was conducted to assess reproduction / developmental toxicity for the substance. The oral administration of triisopropylsilyl acrylate to rats by gavage, at dose levels of 750, 150 and 30 mg/kg/day, resulted in treatment-related effects in litters (reduced litter weights, reduced mean bodyweight gains and litter size of offspring) at 750 mg/kg/day, therefore, the ‘No Observed Effect Level’ (NOEL) was considered to be 150 mg/kg/day for reproductive toxicity. No other treatment-related effects were observed neither parental animals or offspring.
Effect on developmental toxicity: via oral route
- Dose descriptor:
- NOAEL
- 750 mg/kg bw/day
Additional information
As a result of the reproduction / developmental screening study, the treatment-related effects were observed. However, due to the lack of evidence of adverse effects for these observations, it is reasonable to derive the NOAEL in reproductive and developmental toxicity for triisopropylsilyl acrylate is 750 mg/kg/day in the test condition. It is not possible to derive the separate NOAEL for fertility and developmental/teratogenicity due to the limitation of the study design.
The methodology of the test meets the requirements of OECD Test Guideline 421 and is assigned to be reliability 1 data according to the scoring system of Klimisch et al (Klimischet al.,1997). This ranking was deemed appropriate because the study was conducted the GLP certified laboratory and was in compliance with agreed protocols, with no or minor deviations from standard test guidelines and/or minor methodological deficiencies, which do not affect the quality of relevant results.
Justification for classification or non-classification
The test material does not meet the criteria for classification according to EU classification system (Council Directive 67/548/EEC and Regulation (EC) No 1272/2008).
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
