Registration Dossier
Registration Dossier
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EC number: 457-670-6 | CAS number: 157859-20-6
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
There are two studies available for toxicity to aquatic algae and cyanobacteria for triisopropylsilyl acrylate. The Algal Growth Inhibition Test using Scenedesmus subspicatus (reliability of 1, according to the scoring system of Klimisch et al., 1997) gave the 72-hour EC50 value in growth rate of 0.070 mg/l, whereas the algal study using Selenastrum capricornutm Printz (reliability of 4) gave the 72-hour EC50 value in cell density of 0.46 mg/L.
The concentrations used in the S. capricornutm study (geometric series of 0.31, 0.63, 1.3, 2.5 and 5.0 mg/l) was much higher than those in the S. subspicatus study (geometric mean measured test concentration series of 0.000062, 0.00010, 0.0037, 0.014, 0.044 and 0.11 mg/l) and there is a concern with the reliability of the data.
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 0.07 mg/L
- EC10 or NOEC for freshwater algae:
- 0 mg/L
Additional information
The concentrations used in the S. capricornutm study was much higher than those in the S. subspicatus study and there is a concern with the reliability of the data, addressed in the migrated SNIF#001-5.5.00-01.
The Algal Growth Inhibition Test using S. subspicatus is more relevant to be submitted as a key study of this endpoint, because of the quality of the relevant results as well as the dose selection in the study.
Therefore, this study was used for PNEC calculation as well as the classification and labelling of the aquatic environment.Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
