Registration Dossier
Registration Dossier
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EC number: 457-670-6 | CAS number: 157859-20-6
Endpoint summary
Administrative data
Description of key information
There are two acute studies available for this substance, via oral and inhalation routes. The acute oral median lethal dose (LD50) of the test material in the female Sprague-Dawley CD strain rat was estimated to be greater than 2500 mg/kg bodyweight.
In acute inhalation study, no deaths occurred in a group of 10 rats exposed to a mean achieved atmosphere concentration of 5.99 mg/L for 4 hours. It was therefore considered that the acute inhalation median lethal concentration (4 h LC50) of triisopropylsilyl acrylate, in the Sprague-Dawley Crl:CD® (SD) IGS BR strain rat, was greater than 5.99 mg/L.
In accordance with column 2 of Regulation (No) 1907/2006 (REACH) Annex VIII, acute toxicity: dermal (required in section 7.2.3) does not need to be conducted as the skin contact in production and/or use is unlikely due to its pattern of use.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 2 500 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Dose descriptor:
- LC50
- Value:
- 5 990 mg/m³
Acute toxicity: via dermal route
Endpoint conclusion
- Value:
- mg/kg bw
Additional information
There are two acute studies available for this substance, via oral and inhalation routes. The acute oral median lethal dose (LD50) of the test material in the female Sprague-Dawley CD strain rat was estimated to be greater than 2500 mg/kg bodyweight.
In acute inhalation study, no deaths occurred in a group of 10 rats exposed to a mean achieved atmosphere concentration of 5.99 mg/L for 4 hours. It was therefore considered that the acute inhalation median lethal concentration (4 h LC50) of triisopropylsilyl acrylate, in the Sprague-Dawley Crl:CD® (SD) IGS BR strain rat, was greater than 5.99 mg/L.
In accordance with column 2 of Regulation (No) 1907/2006 (REACH) Annex VIII, acute toxicity: dermal (required in section 7.2.3) does not need to be conducted as the skin contact in production and/or use is unlikely due to its pattern of use.
The acute toxicity tests described above meet the requirements of OECD Test Guidelines and are assigned to be reliability 1 data according to the scoring system of Klimisch et al (Klimisch et al., 1997). This ranking was deemed appropriate because the studies were conducted the GLP certified laboratory and were in compliance with agreed protocols, with no or minor deviations from standard test guidelines and/or minor methodological deficiencies, which do not affect the quality of relevant results.
Justification for classification or non-classification
Based on the available information, the substance does not meet the criteria for classification according to EU classification system (Council Directive 67/548/EEC and Regulation (EC) No 1272/2008).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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