Registration Dossier

Administrative data

Description of key information

There are two acute studies available for this substance, via oral and inhalation routes. The acute oral median lethal dose (LD50) of the test material in the female Sprague-Dawley CD strain rat was estimated to be greater than 2500 mg/kg bodyweight. 
In acute inhalation study, no deaths occurred in a group of 10 rats exposed to a mean achieved atmosphere concentration of 5.99 mg/L for 4 hours. It was therefore considered that the acute inhalation median lethal concentration (4 h LC50) of triisopropylsilyl acrylate, in the Sprague-Dawley Crl:CD® (SD) IGS BR strain rat, was greater than 5.99 mg/L.
In accordance with column 2 of Regulation (No) 1907/2006 (REACH) Annex VIII, acute toxicity: dermal (required in section 7.2.3) does not need to be conducted as the skin contact in production and/or use is unlikely due to its pattern of use.

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion
Dose descriptor:
LD50
2 500 mg/kg bw

Acute toxicity: via inhalation route

Endpoint conclusion
Dose descriptor:
LC50
5 990 mg/m³

Acute toxicity: via dermal route

Endpoint conclusion

Additional information

There are two acute studies available for this substance, via oral and inhalation routes. The acute oral median lethal dose (LD50) of the test material in the female Sprague-Dawley CD strain rat was estimated to be greater than 2500 mg/kg bodyweight.

In acute inhalation study, no deaths occurred in a group of 10 rats exposed to a mean achieved atmosphere concentration of 5.99 mg/L for 4 hours. It was therefore considered that the acute inhalation median lethal concentration (4 h LC50) of triisopropylsilyl acrylate, in the Sprague-Dawley Crl:CD® (SD) IGS BR strain rat, was greater than 5.99 mg/L.

In accordance with column 2 of Regulation (No) 1907/2006 (REACH) Annex VIII, acute toxicity: dermal (required in section 7.2.3) does not need to be conducted as the skin contact in production and/or use is unlikely due to its pattern of use.

The acute toxicity tests described above meet the requirements of OECD Test Guidelines and are assigned to be reliability 1 data according to the scoring system of Klimisch et al (Klimisch et al., 1997). This ranking was deemed appropriate because the studies were conducted the GLP certified laboratory and were in compliance with agreed protocols, with no or minor deviations from standard test guidelines and/or minor methodological deficiencies, which do not affect the quality of relevant results.

Justification for classification or non-classification

Based on the available information, the substance does not meet the criteria for classification according to EU classification system (Council Directive 67/548/EEC and Regulation (EC) No 1272/2008).