Registration Dossier
Registration Dossier
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 219-514-3 | CAS number: 2451-62-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
In a 90-day oral toxicity study in rats the NOAEL was determined to be 1.05 mg/kg/day, based on hematological effects and effects in the mesentheric lymph nodes. Dosing up to 50 mg/kg/day caused severe body weight reduction, and lymphoid depletion of spleen and thymus.
In a 5-day mouse inhalation study with exposures for 6 hours per day, at 100, 300 and 750 mg/m3 air caused significant mortality but exposure was too short to see organ effects. No NOAEL was established indicating that the NOAEL is < 100 mg/m3 air.
In a 26-week skin -tumour promotion study no toxic effects were observed apart from acanthosis at the application site indicating that TGIC did not penetrate the skin in significant amounts except to cause irritqtion and sensitization.
A study with mice , dogs, guinea pigs and white rabbits using the intravenous route of exposure, showed mortality, reduced organ weights, haematological effects and signs of neurotoxicity especially in dogs. However, dosing was too short (5 daily injections) to get a clear picture of the neurological effects.
Key value for chemical safety assessment
Repeated dose toxicity: via oral route - systemic effects
Endpoint conclusion
- Dose descriptor:
- NOAEL
- 1.05 mg/kg bw/day
Repeated dose toxicity: inhalation - systemic effects
Endpoint conclusion
- Dose descriptor:
- LOAEC
- 25 mg/m³
Repeated dose toxicity: dermal - systemic effects
Endpoint conclusion
- Dose descriptor:
- NOAEL
- 200 mg/kg bw/day
Additional information
The effects observed in studies with oral, inhalation and intravenous exposure to various concentrations of TGIC showed as major effects mortality, body weight and organ weight reductions ( due to palatability effects in the oral study), hematological effects (reduced leucocyte and lymphocyte numbers), effects on the mesenteric lymph system and depletion of lymphocytes in the thymus and spleen, as well as some clinical signs in dogs which could be interpreted as neurological effects at high dose levels..
As TGIC is rapidly hydrolysed and excreted, no accumulation of the substance is to be expected in the organism, and delayed effects are unlikely.
Alltogether TGIC is harmfull by the oral and inhalation route, but no significant organ effects are to be expected by the dermal route, apart from skin sensitization and skin irritation.
Repeated dose toxicity: via oral route - systemic effects (target organ) cardiovascular / hematological: hematopoiesis
Repeated dose toxicity: inhalation - systemic effects (target organ) cardiovascular / hematological: hematopoiesis
Repeated dose toxicity: dermal - systemic effects (target organ) other: skin
Justification for classification or non-classification
Based on the effects observed in the 90 -day oral toxicity study and in the short-term inhalation study the classification as Harmful (Xn) and R48/22 is fully justified.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
