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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1985
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: GLP and guideline followede, all data available
Cross-referenceopen allclose all
Reason / purpose for cross-reference:
reference to same study
Reason / purpose for cross-reference:
reference to other study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1985
Report date:
1985

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
Deviations:
no
GLP compliance:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
1,3,5-tris(oxiranylmethyl)-1,3,5-triazine-2,4,6(1H,3H,5H)-trione
EC Number:
219-514-3
EC Name:
1,3,5-tris(oxiranylmethyl)-1,3,5-triazine-2,4,6(1H,3H,5H)-trione
Cas Number:
2451-62-9
Molecular formula:
C12H15N3O6
IUPAC Name:
tris[(oxiran-2-yl)methyl]-1,3,5-triazinane-2,4,6-trione
Constituent 2
Reference substance name:
1,3,5-tris(oxiran-2-ylmethyl)-1,3,5-triazine-2,4,6-trione
IUPAC Name:
1,3,5-tris(oxiran-2-ylmethyl)-1,3,5-triazine-2,4,6-trione
Details on test material:
TEPIC-C, sample C,

Test animals

Species:
rabbit
Strain:
New Zealand White
Details on test animals or test system and environmental conditions:
rabbits were 12 - 16 weeks old, with a weight of 2.24 - 2.60 kg, and kept in individual cages.
The animals rooms had 15 cycles of air per hour, a temperature of 18-23 °C, and a relative humidity of 45 - 55 %.
A 12hour dark/light cycle was applied.

Test system

Type of coverage:
semiocclusive
Preparation of test site:
shaved
Vehicle:
water
Controls:
not required
Amount / concentration applied:
0.4 gm in 1 ml of water
Duration of treatment / exposure:
4 hours
Observation period:
72 hours
Number of animals:
3
Details on study design:
animals were shave on the back, and TGIC suspension was applied on an area of 2 x 2 cm, and covered with a semi-occlusive bandage for 4 hours. Reading was at 4, 24, 48, and 72 hours.
Body weight was measured daily

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
erythema score
Basis:
mean
Time point:
24/48/72 h
Score:
ca. 0
Max. score:
4
Reversibility:
other: no irritation observed
Remarks on result:
no indication of irritation
Irritation parameter:
edema score
Basis:
mean
Time point:
24/48/72 h
Score:
ca. 0
Max. score:
4
Reversibility:
other: No irritation observed
Remarks on result:
no indication of irritation
Irritant / corrosive response data:
same responsed observed at 24, 48, and 72 hours (0.0)
Other effects:
Body weight development was similar to concurrent control animals of different study.

Applicant's summary and conclusion

Interpretation of results:
not irritating
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
TEPIC-C, sample C, was not irritant to skin in the assay with rabbits when treatment was 4 hours
Executive summary:

TEPIC-C, sample C, was not irritant to skin in the assay with rabbits when treatment was 4 hours