Registration Dossier

Toxicological information

Acute Toxicity: other routes

Currently viewing:

Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
disregarded due to major methodological deficiencies
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Documentation insufficient for assessment

Data source

Reference
Reference Type:
publication
Title:
Short-term toxicity tests on the mono and di methyl ethers of hydroquinone
Author:
Hodge HC, Sterner JH, Maynard EA and Thomas J .
Year:
1949
Bibliographic source:
The Journal of Industrial Hygiene and Toxicolology, 31(2), 79-92.

Materials and methods

Principles of method if other than guideline:
Other (see Test conditions)
GLP compliance:
no
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
Monomethyl ether hydroquinone (PMP). No other information available.

Test animals

Species:
mouse
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
not specified
Doses:
4, 8, 10, 11, 12, 14, 16, 18 mg/mouse
No. of animals per sex per dose:
10 to 22 per dose

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
ca. 430 mg/kg bw

Any other information on results incl. tables

Dose        No.         Mean body         Mortality        Equiv. dose
(mg)        mice        weight(g)        (%)                (mg/kg bw)
--------------------------------------------------------------------
4        22        26                0                154
8        22        27                5                296
10        20        25                50                400
11        20        29                65                379
12        20        27                40                444
14        20        28                85                500
16        22        27                82                593
18        10        28                100                643

- Clinical signs: mice developed a wobbly gait immediately following injection. This was followed in a few minutes by paralysis of the hind  

quarters, accompanied by spasms perhaps of anoxial origin. At the higher dose the mice appeared to be in a narcosis about 15 minutes 

after injection. Some mice still exhibited degrees of anesthesia as long as 18 hours after the injection.
- Body weight and weight gain: data not available.
- Gross pathology: data not available.

The LD50 is of the order of 430 mg/kg bw.

Applicant's summary and conclusion