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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: Very few information is available about the test conditions. Only 2 doses and 2 animals/group were used.

Data source

Reference
Reference Type:
other company data
Title:
Unnamed
Year:
1959
Report Date:
1959

Materials and methods

Principles of method if other than guideline:
Method: other: no data.
GLP compliance:
no
Limit test:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
Test substance: no data

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Vehicle:
other: corn oil
Doses:
1000; 2000 mg/kg bw
No. of animals per sex per dose:
2 per dose
Control animals:
not specified
Statistics:
no data

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 1 000 - < 2 000 mg/kg bw

Any other information on results incl. tables

DOSE           mortality     Observations
-------------------------------------------------------------------------- ---------------------               
1000 mg/kg bw       0/2       Kidney damage observed at autopsy
2000 mg/kg bw      2/2       Convulsions in 10 mins and depression in 2  hrs. Animals dead in 2 hours.
-------------------------------------------------------------------------- ---------------------

Applicant's summary and conclusion

Interpretation of results:
Category 4 based on GHS criteria
Executive summary:

As the LD50, by oral route in the rat is >1000 mg/kg bw and < 2000 mg/kg bw, PMP is harmful if swallowed, according to the EU CLP Regulation (EC) n°1272/2008 (acute toxicity category 4). This is also the official classification.