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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: Very few information is available about the test conditions. Only 2 doses and 2 animals/group were used.

Data source

Reference
Reference Type:
other company data
Title:
Unnamed
Year:
1959
Report date:
1959

Materials and methods

Principles of method if other than guideline:
Method: other: no data.
GLP compliance:
no
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
Mequinol
EC Number:
205-769-8
EC Name:
Mequinol
Cas Number:
150-76-5
Molecular formula:
C7H8O2
IUPAC Name:
4-methoxyphenol
Details on test material:
Test substance: no data

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Vehicle:
other: corn oil
Doses:
1000; 2000 mg/kg bw
No. of animals per sex per dose:
2 per dose
Control animals:
not specified
Statistics:
no data

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 1 000 - < 2 000 mg/kg bw

Any other information on results incl. tables

DOSE           mortality     Observations
-------------------------------------------------------------------------- ---------------------               
1000 mg/kg bw       0/2       Kidney damage observed at autopsy
2000 mg/kg bw      2/2       Convulsions in 10 mins and depression in 2  hrs. Animals dead in 2 hours.
-------------------------------------------------------------------------- ---------------------

Applicant's summary and conclusion

Interpretation of results:
Category 4 based on GHS criteria
Executive summary:

As the LD50, by oral route in the rat is >1000 mg/kg bw and < 2000 mg/kg bw, PMP is harmful if swallowed, according to the EU CLP Regulation (EC) n°1272/2008 (acute toxicity category 4). This is also the official classification.