Registration Dossier

Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
disregarded due to major methodological deficiencies
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: Very few information are available.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1959

Materials and methods

Principles of method if other than guideline:
Method: other: no data.
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
4-Methoxyphenol. No other information available.

Test animals / tissue source

Species:
rabbit
Strain:
not specified

Test system

Vehicle:
other: propylene glycol
Controls:
not specified
Amount / concentration applied:
undiluted
other: no data.
Details on study design:
Comment: other: unwashed and washed with water.

Results and discussion

Any other information on results incl. tables

  table of results:

 Material  treatment  observations
 Undiluted  unwashed  slight pain, mod. conjunctivitis, corneal damage and slight iritis essantially subsided in 1 week
 Undiluted  washed with water  Same as above except completely subsided in 1 week.
 10% in PG  washed & unwashed  Mod. pain and slight conjunctivitis subsided in 1 hour.

Applicant's summary and conclusion

Interpretation of results:
other: no conclusion possible
Conclusions:
In view of the results of this assay, no conclusion can be drawn concerning the classification of 4-methoxyphenol.
PMP is however officially classified, according to the Directive 67/548/EEC Annex I (Xi R36), and to the EU CLP Regulation (EC) n°1272/2008
(eye irritant category 2).