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EC number: 205-769-8 | CAS number: 150-76-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Toxicity to terrestrial plants
Administrative data
- Endpoint:
- toxicity to terrestrial plants: short-term
- Type of information:
- experimental study
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: The test conditions are not in accordance in the OECD test guideline (the seeds were exposed to solutions of the test substance on filter paper), and the study is not sufficiently described.
Data source
Reference
- Reference Type:
- publication
- Title:
- Mechanism-based quantitative structure-activity relationships for the inhibition of substituted phenols on germination rate of Cucumis sativus.
- Author:
- Wang X, Yu J, Wang Y, Wang L
- Year:
- 2 002
- Bibliographic source:
- Chemosphere, 46(2), 241-250
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The seed germination of Cucumis sativus was measured by a filter paper contact method.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Mequinol
- EC Number:
- 205-769-8
- EC Name:
- Mequinol
- Cas Number:
- 150-76-5
- Molecular formula:
- C7H8O2
- IUPAC Name:
- 4-methoxyphenol
Constituent 1
Sampling and analysis
- Analytical monitoring:
- not specified
Test substrate
- Vehicle:
- not specified
- Details on preparation and application of test substrate:
- Details on preparation and application of test substrate:
- Method of application to filter paper (if used): no data
- Method of mixing into soil (if used): no soil used
- Controls: deionized water
- Chemical name of vehicle (organic solvent, emulsifier or dispersant): no data
- Concentration of vehicle in test medium (stock solution and final test solution): no data
- Evaporation of vehicle before use: no data
Test organisms
- Species:
- other: other terrestrial plant: Cucumis sativus
- Plant group:
- Dicotyledonae (dicots)
- Details on test organisms:
- - Common name: Cucumber
- Plant family: Cucurbitaceae
- Variety: no data
- Source of seed: no data
- Prior seed treatment/sterilization: no data
- Historical germination of seed (germination of seed lot tested): no data
- Seed storage: no data
Study design
- Test type:
- seedling emergence toxicity test
- Study type:
- laboratory study
- Substrate type:
- filter paper
- Limit test:
- no
- Total exposure duration:
- 2 d
- Post exposure observation period:
- no data
Test conditions
- Test temperature:
- 25+/- 1°C
- pH:
- no data
- Moisture:
- not applicable
- Details on test conditions:
- TEST SYSTEM
- Testing facility:
- Test container (type, material, size): 100 X 15 mm² disposable petri dishes and Whatman No. 1
filter paper.
- Method of seeding: no data
- Nb. of seeds per container: no data
- Nb. of plants (retained after thinning): no data
- Nb. of replicates per treatment group: 4
- Nb. of replicates per control:4
GROWTH CONDITIONS
- Photoperiod: Dark
- Relative humidity (%): No data
- Wind velocity: No data
- Air exchange rate: No data
- Watering regime and schedules: solutions were renewed every 12 h to achieve semi-static exposure.
- Water source/type: deionized water
- Volume applied: 5 mL
- Interval of applications: No data
- Method of application: no data
ACCLIMATION PERIOD: No data
EFFECT PARAMETERS MEASURED Germination rate
VEHICLE CONTROL PERFORMED: no data
TEST CONCENTRATIONS
- Spacing factor for test concentrations: no data
- Range finding study: no data
- Test concentrations: no data
STATISTIC GC50, concentration at which the average germination rate was 50% of those in the
corresponding control, was calculated by the log-linear regression in STATISTICA for Windows
software (version 5.0). - Nominal and measured concentrations:
- 6 concentrations ranging from no effect to 100% inhibition concentration.
- Reference substance (positive control):
- not specified
Results and discussion
Effect concentrations
- Species:
- Cucumis sativus
- Duration:
- 2 d
- Dose descriptor:
- EC50
- Effect conc.:
- 229.3 other: mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- seedling emergence
- Details on results:
- SEED GERMINATION
- Percent seed germination: no data
- Root length: not recorded
- Root discolouration/malformation: not recorded
- Results with reference substance valid: not applicable
SEEDLING EMERGENCE
- Percent seedling emergence: no data
- Percent survival: no data
- Plant height: no data
- Dry weight: no data
- Abnormal seed development or appearance: no data
VEGETATIVE VIGOUR: no data
The average germination rate in the control test ranges from 77% to 88%.
The 50% germination rate inhibition concentration of the test substance: GC50 = 229.3 mg/L
(R² = 0.966, SE = 3.37)
pH of the test solution on germination rate 50% inhibition concentration: 6.23
Applicant's summary and conclusion
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