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endocrine system modulation
Type of information:
experimental study
Adequacy of study:
supporting study
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Scientific publication with appropriate description of the method.
no guideline followed
Principles of method if other than guideline:
The aim of this study was to assess the estrogenic activities of environmentally relevant chemicals including melamine.
Method according to Nishikawa et al. The yeast two-hybrid system is based on the ligand-dependent interaction of two proteins, a hormone receptor and a coactivator, and hormonal activity is detected by ß-galactosidase activity.
GLP compliance:
not specified
Type of method:
in vitro
other: Saccharomyces cerevisiae Y 190
Route of administration:
other: in vitro assay
Duration of treatment / exposure:
Exposure period: 4 hour(s)
Details on study design:
Yeast Two-Hybrid Assay.

Melamine showed no estrogenic activity within the Yeast Two-Hybrid assay.

Description of key information

Melamine showed no estrogenic activity within the Yeast Two-Hybrid assay.

Additional information