Registration Dossier
Registration Dossier
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EC number: 255-449-7 | CAS number: 41583-09-9
Specific investigations: other studies
Administrative data
Link to relevant study record(s)
- Endpoint:
- endocrine system modulation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Scientific publication with appropriate description of the method.
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The aim of this study was to assess the estrogenic activities of environmentally relevant chemicals including melamine.
Method according to Nishikawa et al. The yeast two-hybrid system is based on the ligand-dependent interaction of two proteins, a hormone receptor and a coactivator, and hormonal activity is detected by ß-galactosidase activity. - GLP compliance:
- not specified
- Type of method:
- in vitro
- Species:
- other: Saccharomyces cerevisiae Y 190
- Route of administration:
- other: in vitro assay
- Duration of treatment / exposure:
- Exposure period: 4 hour(s)
- Details on study design:
- Yeast Two-Hybrid Assay.
Reference
Melamine showed no estrogenic activity within the Yeast Two-Hybrid assay.
Description of key information
Melamine showed no estrogenic activity within the Yeast Two-Hybrid assay.
Additional information
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