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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Specific investigations: other studies

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Link to relevant study record(s)

endocrine system modulation
Type of information:
experimental study
Adequacy of study:
supporting study
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Scientific publication with appropriate description of the method.
no guideline followed
Principles of method if other than guideline:
The aim of this study was to assess the estrogenic activities of environmentally relevant chemicals including melamine.
Method according to Nishikawa et al. The yeast two-hybrid system is based on the ligand-dependent interaction of two proteins, a hormone receptor and a coactivator, and hormonal activity is detected by ß-galactosidase activity.
GLP compliance:
not specified
Type of method:
in vitro
other: Saccharomyces cerevisiae Y 190
Route of administration:
other: in vitro assay
Duration of treatment / exposure:
Exposure period: 4 hour(s)
Details on study design:
Yeast Two-Hybrid Assay.

Melamine showed no estrogenic activity within the Yeast Two-Hybrid assay.

Description of key information

Melamine showed no estrogenic activity within the Yeast Two-Hybrid assay.

Additional information