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Long-term toxicity to aquatic invertebrates

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Description of key information


The chronic toxicity and the reproduction toxicity of melamine to Daphnia magna is low.

Key value for chemical safety assessment

Additional information

The chronic toxicity to aquatic invertebrates was assessed in a study conducted according to OECD guideline 211. Daphnia magna was exposed to nominal concentrations of 0, 0.46, 1.0, 2.2, 4.6, 10 mg/L test substance for 22d. The test was conducted as semi-static test. After the exposure time no effects on any of the observed endpoints could be detected. The NOEC based on reproduction was determined to be > 10 mg/L and the LOEC >= 10 mg/L. No significant mortality or any other additional significant adverse effects or abnormal behavior were observed in any of the test treatments. The data were not sufficient to calculate ECx values for reproduction or mortality.

Furthermore, as the substance is a salt of phosphate, effects were read-across from the cation, which is likely to have the more important effects. In biological systems, phosphate is an abundant in cells and body fluids. In ecological terms, because of its important role in biological systems, phosphate is a highly sought-after resource. Thus, read-across from component CAS Reg.-No. 108-78-1, melamine, is justified. All effect values are minimum values as the molar ratio anion:cation equals 1.74. In this study the LOEC 21d for reproduction and mortality was found to be 18 mg/L.

In summary, based on long-term (chronic) toxicity study data, the product is very likely not harmful to aquatic invertebrates.

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