Registration Dossier
Registration Dossier
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EC number: 255-449-7 | CAS number: 41583-09-9
Endpoint summary
Administrative data
Description of key information
Additional information
Stability
Hydrolysis
A weight of evidence approach with the read across source substance melamine (CAS 108-78-1) from the consistent statements in two handbooks (Gmelin, 1971 and Ullmann, 2006) is applied. Melamine is a stable molecule. Melamine is hydrolyzed only by mineral acid or inorganic alkali. Hydrolysis proceeds stepwise, with loss of one, two, or all three amino groups, i.e. producing ammeline, ammelide and cyanuric acid.
Therefore and according to structural properties, hydrolysis is not expected/probable.
Biodegradation
Biodegradation in water: screening test
A weight of evidence approach with the read across substance melamine (CAS 108-78-1) is applied. Based on the reported studies, which are consistent in the result: melamine is not inherently biodegradable and also not readily biodegradable (% degradation (DOC removal) < 10 % in 28 days according to OECD 302 B (1992), (Taeger, 1993 (BASF SE)). Based on this result, the target substance is also considered to be not readily biodegradable. Biodegradation, also stepwise, to cyanuric acid and lastly to CO2 and NH4+ can occur in waste water treatment plants with adapted microorganisms.
Biodegradation in water and sediment: simulation test
A biodegradation in water and sediment simulation test does need not to be conducted. A log kow of -3 (at 25 °C) and a determined log Koc < 1.3 indicate low potential for adsorption to solid soil/sediment . Thus, a simulation test on biodegradation in water and sediment does not need to be conducted.
Biodegradation in soil
A biodegradation in soil does need not to be conducted. A log kow of -3 (at 25 °C) and a determined log Koc < 1.3 indicate low potential for adsorption to solid soil. Thus, a simulation test on biodegradation in soil does not need to be conducted.
Bioaccumulation: aquatic / sediment
A read-across from the source substance CAS 108-78-1, melamine, is justified. The experimental determinations of the bioconcentration factor BCF in 3 species of fish are available. In these studies (Lech, 1984 and Nite, 2010) no bioaccumulation of melamine is expected as the determined bioconcentration factors in fish are < 1 (only at 0.2 ppm the BCF = 3.8). Based on this result, the test substance does not accumulate in organisms. The calculated logPow of -3 at 25 °C (see section 4.7) of the test substance is below the threshold value of 4 (according to GHS criteria) and thus, accumulation in organisms of the test substance is not expected.
Transport and distribution
Adsorption / desorption
A log kow of -3.1 (see section 4.7) was determined which indicates low potential for adsorption to soil. In addition a log Koc of < 1.3 was determined in a study (BASF SE, 2002) performed according to OECD 121 (2001), which supported the low potential for adsorption to soil.
Henry´s constant
The database of the EPA contains an experimentally determined Henrys law constant for melamine of 1.84 x 10exp-14 atm.m3/mol (1.86 x 10exp-9 Pa*m-3*mol-1) at 20 °C. Based on this result the substance will not evaporate into the atmosphere from the water surface.
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