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EC number: 255-449-7 | CAS number: 41583-09-9
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
No data with the test substance were available. A weight of evidence approach with the read across substance melamine (CAS 108-78-1) is applied.
The study of Hockenbury 1977 is the relatively best reported one and was therefore selected as the lead study in the weight of evidence approach. After 2 hours the EC0 was determined to be > 100 mg/L. The toxicity of melamine to three different microorganisms is low.
Key value for chemical safety assessment
Additional information
No data with the target substance were available. A weight of evidence approach with the read across source substance melamine (CAS 108-78-1) is applied (please refer section 13 for the read across justification).
Three old and/or insufficiently reported studies on the toxicity of melamine to different microorganisms are available. A weight of evidence approach is applied. In Pagga, 1979 (BASF SE): Inhibition of respiration of activated sludge the EC20 was determined to be >1992 mg/L, in Hockenbury, 1977: Inhibition of nitrification by Nitrosomonas sp., the EC0, 2h was determined to be >100 mg/L and in Tillmann, 1990 (BASF SE): Inhibition of respiration of Pseudomonas putida the EC0 was determined to be >10000 mg/L. Each of the studies with different endpoints and microorganisms indicates a low toxicity of melamine. The study of Hockenbury 1977 is the relatively best reported one and was therefore selected as the lead study in the weight of evidence approach.
As the substance is a salt of phosphate, effects can be read-across from the cation, which is likely to have the more important effects. In biological systems, phosphate is an abundant in cells and body fluids. In ecological terms, because of its important role in biological systems, phosphate is a highly sought-after resource. Thus, read-across from the read across source substance CAS 108-78-1 is justified. All effect values are minimum values as the molar ratio anion:cation equals 1.74.
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