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EC number: 255-449-7 | CAS number: 41583-09-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
No data with the test substance were available. A weight of evidence approach with the read across substance melamine (CAS 108-78-1) is applied.
The study of Hockenbury 1977 is the relatively best reported one and was therefore selected as the lead study in the weight of evidence approach. After 2 hours the EC0 was determined to be > 100 mg/L. The toxicity of melamine to three different microorganisms is low.
Key value for chemical safety assessment
Additional information
No data with the target substance were available. A weight of evidence approach with the read across source substance melamine (CAS 108-78-1) is applied (please refer section 13 for the read across justification).
Three old and/or insufficiently reported studies on the toxicity of melamine to different microorganisms are available. A weight of evidence approach is applied. In Pagga, 1979 (BASF SE): Inhibition of respiration of activated sludge the EC20 was determined to be >1992 mg/L, in Hockenbury, 1977: Inhibition of nitrification by Nitrosomonas sp., the EC0, 2h was determined to be >100 mg/L and in Tillmann, 1990 (BASF SE): Inhibition of respiration of Pseudomonas putida the EC0 was determined to be >10000 mg/L. Each of the studies with different endpoints and microorganisms indicates a low toxicity of melamine. The study of Hockenbury 1977 is the relatively best reported one and was therefore selected as the lead study in the weight of evidence approach.
As the substance is a salt of phosphate, effects can be read-across from the cation, which is likely to have the more important effects. In biological systems, phosphate is an abundant in cells and body fluids. In ecological terms, because of its important role in biological systems, phosphate is a highly sought-after resource. Thus, read-across from the read across source substance CAS 108-78-1 is justified. All effect values are minimum values as the molar ratio anion:cation equals 1.74.
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