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A weight of evidence approach with the read across source substance melamine (CAS 108-78-1) from the consistent statements in two handbooks (Gmelin, 1971 and Ullmann, 2006) is applied. Melamine is a stable molecule. Melamine is hydrolyzed only by mineral acid or inorganic alkali. Hydrolysis proceeds stepwise, with loss of one, two, or all three amino groups, i.e. producing ammeline, ammelide and cyanuric acid. Therefore and according to structural properties, hydrolysis is not expected/probable.