Registration Dossier
Registration Dossier
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EC number: 255-449-7 | CAS number: 41583-09-9
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2001 - 2002
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 002
- Report date:
- 2002
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- 1,3,5-triazine-2,4,6-triamine phosphate
- EC Number:
- 255-449-7
- EC Name:
- 1,3,5-triazine-2,4,6-triamine phosphate
- Cas Number:
- 41583-09-9
- Molecular formula:
- C3H6N6.xH3O4P
- IUPAC Name:
- 1,3,5-triazine-2,4,6-triamine phosphate
- Details on test material:
- Molecular formula: C3H6N6H3O4P
Molecular weight: 224
CAS number: 41583-09-9
Description: White solid
Batch: Not indicated
Purity: >98%
Test substance storage: At room temperature in the dark
Stability under storage conditions: Not indicated
Specific Gravity: 1.74
Stability in vehicle: At least 96 h in 1% Aq. Carboxymethyl cellulose
Constituent 1
- Specific details on test material used for the study:
- Molecular formula: C3H6N6H3O4P
Molecular weight: 224
CAS number: 41583-09-9
Description: White solid
Batch: Not indicated
Purity: >98%
Test substance storage: At room temperature in the dark
Stability under storage conditions: Not indicated
Specific Gravity: 1.74
Stability in vehicle: At least 96 h in 1% Aq. Carboxymethyl cellulose
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Rat, Wistar strain Cri:(WI) BR (outbred, SPF-Quality). Recognised by intemational guidelines as the recommended test system (e.g. OECD, EC). Source: Charies River Deutschland, Sulzfeld, Germany.
Young adult animals (approx. 6 weeks old) were selected. Body weight variation did not exceed +/- 20% of the sex mean.
Identification by earmark
A controlled environment was maintained in the room with optimal conditions considered as being approximately 15 air changes per hour, a temperature of 21±3°C, a relative humidity of 30-70% and 12 hours artificial fluorescent light and 12 hours dark per day. Temporary deviations from the maximum level for relative humidity (with a maximum of 20%) occurred which might have been caused by cleaning procedures in the room. Based on laboratory historical data these deviations were considered not to have affected the study integrity.
Group housing of 3 animals per sex per cage in labelled Macrolon cages (type IV; height 15 cm) containing purified sawdust as bedding material.
Acclimatisation period was at least 5 days before start of treatment under laboratory conditions.
Free access to diet and water, fasting period 20h
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- CMC (carboxymethyl cellulose)
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 3 males and 3 females
- Control animals:
- no
- Details on study design:
- Mortality/Viability: Twice daily.
Body weights: Days 1 (pre-administration), 8 and 15.
Clinical signs:
At periodic intervals on the day of dosing (day 1) and once daily thereafter, until day 15. The symptoms were graded according to fixed scales and the time of onset, degree and duration were recorded:
Maximum grade 4: grading slight (1) to very severe (4)
Maximum grade 3: grading slight (1) to severe (3)
Maximum grade 1: presence is scored (1).
Necropsy: At the end of the observation period, all animals were sacrificed by asphyxiation using an oxygen/carbon dioxide procedure and subjected to necropsy. Descriptions of all internal macroscopic abnormalities were recorded. - Statistics:
- No statistical analysis was performed (The method used is not intended to allow the calculation of a precise LD50 value).
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LD0
- Effect level:
- >= 2 000 mg/kg bw
- Remarks on result:
- other: No clinical signs, no effects on body weight and no findings upon necropsy.
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- none
- Clinical signs:
- other: none
- Gross pathology:
- no findings
- Other findings:
- none
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
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