Registration Dossier
Registration Dossier
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EC number: 255-449-7 | CAS number: 41583-09-9
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
No data with the test substance were available. A weight of evidence approach with the read across source substance melamine (CAS 108-78-1) is applied. Based on the reported studies, which are consistent, an EC50 of 325 mg/L and a NOEC of 98 mg/L were determined in a study performed with Pseudokirchneriella subcapitata (Drodowski, 1988 (American Cyanamid)). The toxicity of the substance to algae, as measured by growth inhibition, is low.
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 325 mg/L
- EC10 or NOEC for freshwater algae:
- 98 mg/L
Additional information
No data with the test substance were available. A weight of evidence approach with the read across source substance melamine (CAS 108-78-1) is applied. Please refer section 13 for the read across justification of the test substance. The studies revealed EC50 values of 325 and 940 mg/L in the studies (Drozdowski, 1988 (American Cyanamid) and Oldersma, 1982 (DSM), respectively. The NOEC values were determined to be 98 mg/L in Drozdowski, 1988 (American Cyanamid) and 320 mg/L in Oldersma, 1982 (DSM). The compound is not expected to have significant effect on aquatic algae and cyanobacteria.
As the substance is a salt of phosphate, effects can be read-across from the cation, which is likely to have the more important effects. In biological systems, phosphate is an abundant in cells and body fluids. In ecological terms, because of its important role in biological systems, phosphate is a highly sought-after resource. Thus, read-across from the read across source substance melamine CAS 108-78-1 is justified. All effect values are minimum values as the molar ratio anion:cation equals 1.74.
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