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Physical & Chemical properties

Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
9 May - 19 June, 1988
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
Deviations:
not specified
Qualifier:
equivalent or similar to
Guideline:
EU Method A.8 (Partition Coefficient)
Deviations:
not specified
GLP compliance:
yes
Type of method:
shake-flask method to: flask method
Partition coefficient type:
octanol-water
Key result
Type:
log Pow
Partition coefficient:
1.5
Temp.:
20 °C
pH:
7.4
Remarks on result:
other: pH of the water phases and the saturated buffer solutions.
Type:
Pow
Partition coefficient:
35
Temp.:
20 °C
pH:
7.4
Remarks on result:
other: pH of the water phases and the saturated buffer solutions.
Conclusions:
The partition coefficient (n-octanol/water) for Benzonitrile was determined to be 35 (log Pow = 1.5) at 20 +/- 0.5 °C.
Executive summary:

This GLP study was carried out in accordance with the OECD guideline for testing of chemicals number 107 (May 1981) and the EC method A.8, Official Journal of the European Communitites 92/69/EEC, No L 383 (Dec. 1992) with the shake flask method. The octanol/water partition coefficient (Pow) and its logarithm to base 10 (log Pow) were determined to be:

Pow                = 35 at 20 +/- 0.5 °C

log Pow           = 1.5 at 20 +/- 0.5 °C

Description of key information

The partition coefficient (n-octanol/water) for Benzonitrile was determined to be 35 (log Pow = 1.5) at 20 +/- 0.5 °C.

Key value for chemical safety assessment

Log Kow (Log Pow):
1.5
at the temperature of:
20 °C

Additional information