Registration Dossier

Toxicological information

Neurotoxicity

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Administrative data

Endpoint:
neurotoxicity: acute oral
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
1990
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
abstract

Data source

Reference
Reference Type:
publication
Title:
Effects pharmacologiques du benzonitrile sur le systeme nerveux central
Author:
Cheav, S.L., Chalfoun-Mounayar, A., et al.
Year:
1990
Bibliographic source:
Ann. Pharm. Fr., 48, 209-218

Materials and methods

Test guideline
Qualifier:
no guideline available
GLP compliance:
not specified
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
impurity
Type:
impurity
Type:
impurity
Type:
impurity
Type:
impurity
Test material form:
liquid

Test animals

Species:
mouse
Strain:
Swiss
Sex:
male

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
olive oil
Analytical verification of doses or concentrations:
not specified
Duration of treatment / exposure:
single application
Frequency of treatment:
single application
Doses / concentrationsopen allclose all
Dose / conc.:
240 mg/kg bw/day (nominal)
Remarks:
Basis: actual ingested
Dose / conc.:
480 mg/kg bw/day (nominal)
Remarks:
Basis: actual ingested
Dose / conc.:
720 mg/kg bw/day (nominal)
Remarks:
Basis: actual ingested
No. of animals per sex per dose:
10

Results and discussion

Applicant's summary and conclusion

Conclusions:
Based on neuromotor effects, catalepsy and analgesia, it was concluded that benzonitrile could affect catecholaminergic neurones.
Executive summary:

Based on neuromotor effects, catalepsy and analgesia, it was concluded that benzonitrile could affect catecholaminergic neurones.