Registration Dossier

Toxicological information

Acute Toxicity: other routes

Currently viewing:

Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
abstract

Data source

Reference
Reference Type:
publication
Title:
Benzoesäurenitril, Benzonitril, Phenylcyanid
Author:
Stout, A.
Year:
1932
Bibliographic source:
Fortschritte der Heilstoffchemie, 2. Abt., Bd. II

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
no details reported; collection of data
GLP compliance:
no
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
impurity
Type:
impurity
Type:
impurity
Type:
impurity
Type:
impurity
Test material form:
liquid

Test animals

Species:
other: mouse, pigeons and rabbits
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
subcutaneous
Vehicle:
not specified
Doses:
no data reported
No. of animals per sex per dose:
no data
Control animals:
not specified

Results and discussion

Effect levelsopen allclose all
Sex:
not specified
Dose descriptor:
EC50
Effect level:
180 mg/kg bw
Based on:
test mat.
Remarks on result:
other: mouse
Sex:
not specified
Dose descriptor:
EC50
Effect level:
500 mg/kg bw
Based on:
test mat.
Remarks on result:
other: pigeons
Sex:
not specified
Dose descriptor:
EC50
Effect level:
200 mg/kg bw
Based on:
test mat.
Remarks on result:
other: rabbit

Applicant's summary and conclusion

Conclusions:
The abstract cites studies which determined lethal doses (subcutaneous) for mouse = 180 mg/kg, pigeons = 500 mg/kg and rabbits = 200 mg/kg.
Executive summary:

The abstract cites studies which determined lethal doses (subcutaneous) for mouse = 180 mg/kg, pigeons = 500 mg/kg and rabbits = 200 mg/kg.