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Toxicological information

Repeated dose toxicity: oral

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Administrative data

Endpoint:
short-term repeated dose toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
abstract

Data source

Referenceopen allclose all

Reference Type:
secondary source
Title:
Unnamed
Year:
2000
Report Date:
2000
Reference Type:
publication
Title:
Etude comparee de la toxicite de derives cyanes et/ou amides aromatiques
Author:
Cheav, S.L., Foussard-Blanpin, O.
Year:
1990
Bibliographic source:
Ann. Pharm. Fr., 48, 23-31

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 407 (Repeated Dose 28-Day Oral Toxicity in Rodents)
Deviations:
not specified
GLP compliance:
not specified
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
impurity
Type:
impurity
Type:
impurity
Type:
impurity
Type:
impurity
Test material form:
liquid

Test animals

Species:
rat
Strain:
Wistar
Sex:
male/female

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
olive oil
Analytical verification of doses or concentrations:
not specified
Duration of treatment / exposure:
28 days
Frequency of treatment:
daily
Doses / concentrations
Dose / conc.:
40 mg/kg bw/day (nominal)
Remarks:
Basis:
actual ingested
No. of animals per sex per dose:
5
Control animals:
yes

Results and discussion

Effect levels

Key result
Dose descriptor:
NOAEL
Effect level:
40 mg/kg bw/day (actual dose received)
Based on:
test mat.
Sex:
male/female
Basis for effect level:
other: mortality; body weight; gross pathology; behavior

Target system / organ toxicity

Critical effects observed:
not specified

Applicant's summary and conclusion

Conclusions:
Application or 40 mg benzonitrile/kg/d for 28 days did not cause any adverse effect in Wistar rats.
Executive summary:

Application or 40 mg benzonitrile/kg/d for 28 days did not cause any adverse effect in Wistar rats.