Registration Dossier

Administrative data

Endpoint:
short-term repeated dose toxicity: other route
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
abstract

Data source

Referenceopen allclose all

Reference Type:
secondary source
Title:
Unnamed
Year:
2000
Report Date:
2000
Reference Type:
publication
Title:
Etude comparee de la toxicite de derives cyanes et/ou amides aromatiques
Author:
Cheav, S.L.,Foussard-Blanpin, O.
Year:
1990
Bibliographic source:
Ann. Pharm. Fr., 41, 391-394

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
i.p. injection of 30 mg benzonitrile/kg (in rat)
GLP compliance:
not specified
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
impurity
Type:
impurity
Type:
impurity
Type:
impurity
Type:
impurity
Test material form:
liquid

Test animals

Species:
rat
Strain:
Wistar
Sex:
male/female

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
not specified
Analytical verification of doses or concentrations:
not specified
Duration of treatment / exposure:
4 weeks
Frequency of treatment:
daily
Doses / concentrations
Dose / conc.:
30 mg/kg bw/day (nominal)
No. of animals per sex per dose:
5
Control animals:
yes

Results and discussion

Target system / organ toxicity

Critical effects observed:
not specified

Any other information on results incl. tables

3 amimals died during day 19-22. Gross pathology revealed adverse effects in spleen, pancreas, lung and hemorrhagic necrosis in the kidney (cortex).

Applicant's summary and conclusion

Conclusions:
After application of 30 mg benzonitrile/kg 3/10 rats died at day 19-22. Gross pathology revealed adverse effects in spleen, pancreas, lung and hemorrhagic necrosis in the kidney (cortex).
Executive summary:

After application of 30 mg benzonitrile/kg 3/10 rats died at day 19-22. Gross pathology revealed adverse effects in spleen, pancreas, lung and hemorrhagic necrosis in the kidney (cortex).