Registration Dossier

Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Pre-GLP study

Data source

Reference
Reference Type:
publication
Title:
The Acute Toxicity of Cyanogen
Author:
J.M.McNerney, M.P.H., H.H.Schrenk, PhD.
Year:
1960
Bibliographic source:
J.M.McNerney, M.P.H., H.H.Schrenk, PhD., The Acute Toxicity of Cyanogen, Industrial Hygiene Foundation, 4400 Fifth Avenue, Pittsburg 13, Pennsylvania, Industrial Hygiene Journal, 1960, 121 – 124

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
EU Method B.2 (Acute Toxicity (Inhalation))
Deviations:
yes
Remarks:
shorter exposure time (1 hr), smaller number of tested animals per group.
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
rat
Sex:
male

Administration / exposure

Route of administration:
inhalation: gas
Type of inhalation exposure:
whole body
Vehicle:
air
No. of animals per sex per dose:
6
Control animals:
no

Results and discussion

Effect levelsopen allclose all
Sex:
male
Dose descriptor:
LC50
Effect level:
350 ppm
Based on:
test mat.
Exp. duration:
1 h
Sex:
male
Dose descriptor:
LC0
Effect level:
250 ppm
Based on:
test mat.
Exp. duration:
1 h

Applicant's summary and conclusion

Interpretation of results:
Toxicity Category II
Remarks:
Migrated information Criteria used for interpretation of results: EU
Executive summary:

Cyanogen was found to be toxic for male albino rats by inhalation with LC50 350 ppm ethanedinitrile/1 hour. For the purpose of classification, AF 2 was used to derive 4hrs LC50 from 1hr value resulting in LC50 175 ppm/ 4 hrs.