Registration Dossier

Administrative data

Endpoint:
sub-chronic toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
publication
Title:
Toxicity evaluation of sub-chronic exposures to cyanogen in rats and monkeys
Author:
Trent R. Lewis, W. Kent Anger, R. Kent Te Vault
Year:
1984
Bibliographic source:
Lewis T.R., Anger WK, Te Vault RK, Toxicity evaluation of sub-chronic exposures to cyanogen in monkeys and rats, J Environ Pathol Toxicol Oncol 5:151-163, 1984

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
6-months exposure period(5 days/week, 6 hrs/day) to 0, 11 and 25 ppm of cyanogen
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
other: rat, monkey

Administration / exposure

Route of administration:
inhalation: gas
Type of inhalation exposure:
whole body

Results and discussion

Results of examinations

Clinical signs:
no effects observed
Mortality:
no mortality observed
Body weight and weight changes:
effects observed, treatment-related
Organ weight findings including organ / body weight ratios:
effects observed, treatment-related
Details on results:
One monkey died due to exposure unrelated reason, apart from that, all animals lived through whole experiment.
Rats exposed to 25 ppm of cyanogen showed statistically significant lowered body weight (470 g vs. 543 g in control group). Monkeys exposed to 25 ppm of cyanogen showed lower moisture content in lungs.

Effect levels

open allclose all
Dose descriptor:
NOAEC
Effect level:
11 ppm
Based on:
test mat.
Dose descriptor:
LOAEC
Effect level:
25 ppm
Based on:
test mat.

Target system / organ toxicity

Critical effects observed:
not specified

Applicant's summary and conclusion

Conclusions:
Rats exposed to 25 ppm of cyanogen showed statistically significant lowered body weight (470 g vs. 543 g in control group). Monkeys exposed to 25 ppm of cyanogen showed lower moisture content in lungs.