Registration Dossier

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
publication
Title:
The Acute Toxicity of Cyanogen
Author:
J.M.McNerney, M.P.H., H.H.Schrenk, PhD.
Year:
1960
Bibliographic source:
J.M.McNerney, M.P.H., H.H.Schrenk, PhD., The Acute Toxicity of Cyanogen, Industrial Hygiene Foundation, 4400 Fifth Avenue, Pittsburg 13, Pennsylvania, Industrial Hygiene Journal, 1960, 121 – 124

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
EU Method B.3 (Acute Toxicity (Dermal))
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
rabbit
Sex:
male

Administration / exposure

Type of coverage:
open
Vehicle:
other: air
Duration of exposure:
8hrs
Doses:
up to 10,000 ppm

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LD0
Effect level:
> 10 000 other: ppm
Based on:
test mat.

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Executive summary:

8-hour exposure of male albino rabbits to cyanogen concentration up to 10,000 ppm resulted in no macroscopic effects, at autopsy, no pathological changes were identified