Registration Dossier

Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
publication
Title:
The Acute Toxicity of Cyanogen
Author:
J.M.McNerney, M.P.H., H.H.Schrenk, PhD.
Year:
1960
Bibliographic source:
J.M.McNerney, M.P.H., H.H.Schrenk, PhD., The Acute Toxicity of Cyanogen, Industrial Hygiene Foundation, 4400 Fifth Avenue, Pittsburg 13, Pennsylvania, Industrial Hygiene Journal, 1960, 121 – 124

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Two types of exposure were employed. One in which humans were exposed to the gas in the sealed room, the other in which humans attempted to detect the odor of the gas by breathing through a tube attached to the small chamber.
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
other: gas

Test animals / tissue source

Species:
other: human

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Remarks:
1
Basis:
mean
Time point:
other: 0
Score:
1
Max. score:
1
Reversibility:
fully reversible within: several minutes

Applicant's summary and conclusion

Interpretation of results:
irritating
Remarks:
Migrated information Criteria used for interpretation of results: expert judgment
Executive summary:

16 ppm of cyanogen caused almost immediate eye irritation which faded away several minutes after the end of exposure. 8 ppm of cyanogen caused no eye irritation at all.