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Diss Factsheets

Administrative data

Description of key information

Oral exposure is not possible due to physicochemical properties of ethanedinitrile.


Dermal exposure- no adverse effect observed


Inhalation exposure - according CLP - Acute tox. 2; H220

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records
Reference
Endpoint:
acute toxicity: oral
Data waiving:
study scientifically not necessary / other information available
Justification for data waiving:
the study does not need to be conducted because a study on acute toxicity by the inhalation route is available
Endpoint conclusion
Endpoint conclusion:
no study available

Acute toxicity: via inhalation route

Endpoint conclusion
Endpoint conclusion:
adverse effect observed
Dose descriptor:
LC50
Value:
>= 136.46 - <= 136.46 ppm air
Physical form:
inhalation: gas

Acute toxicity: via dermal route

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed

Additional information

Table 8.7.2.-1: Ethanedinitrile acute inhalation toxicity

Study - inhalatory

Test organism

Dose (ppm)/

exposure time (minutes)

Mortality ratio (dead/dosed)

Report References

Nose-only exposure

Rat (male and female)

63.14 /4h

0/10

Product Safety Lab 2017

128.02 /4h

1/5

181.56 /4h

6/10

Inhal exposure

Rat

4,000 / 7.5

3/6

McNerney and Schrenk 1960

4,000 / 15

6/6

2,000 / 7.5

0/6

2,000 / 15

6/6

1,000 / 15

0/6

1,000 / 30

6/6

500 / 30

0/6

500 / 45

6/6

400 / 45

0/6

400 / 60

6/6

250 / 60

0/6

250 / 120

4/6

control

0/6

Inhal exposure

Frog

 8,000 / 1

 

Fatal within 1 day

Flury and Zernik 1931

10,000 / 3

Fatal within 30 min

Mouse

235 / 15

Recovered

2,600 / 12

Fatal

15,000 / <1

Fatal

Rabbit

100 / 4 hours

Almost without effect

200 / 4 hours

Slight symptoms

300 / 3.5 hours

Serious symptoms, died later

400/ 105

Fatal

Cat

50 / 4 hours

Serious symptoms but recovered

75 / 4 hours

Fatal within 2 days of exposure

100 / 2–3 hours

Fatal

200 / 30

Fatal

2,000 / 13

Fatal

Justification for classification or non-classification

Oral exposure is not possible due to physicochemical properties of ethanedinitrile.

Dermal exposure- no adverse effect observed

Inhalation exposure - according CLP - Acute tox. 2; H220