Registration Dossier

Administrative data

Description of key information

Key value for chemical safety assessment

Skin irritation / corrosion

Link to relevant study records
Reference
Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Reference:
Composition 0
Qualifier:
equivalent or similar to
Guideline:
EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion)
Deviations:
yes
Remarks:
8-hour exposure of whole body except head
GLP compliance:
no
Test material information:
Composition 1
Species:
rabbit
Duration of treatment / exposure:
8 hours
Irritation parameter:
overall irritation score
Remarks:
0
Time point:
other: 0
Score:
0
Max. score:
0
Reversibility:
other: no irritation occured
Interpretation of results:
not irritating
Remarks:
Migrated information Criteria used for interpretation of results: EU
Executive summary:

During 8-hour exposure of male albino rabbits to cyanogen concentrations up to 10,000 ppm, no signs of irritation occured.

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Eye irritation

Link to relevant study records
Reference
Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Reference:
Composition 0
Qualifier:
no guideline followed
Principles of method if other than guideline:
Two types of exposure were employed. One in which humans were exposed to the gas in the sealed room, the other in which humans attempted to detect the odor of the gas by breathing through a tube attached to the small chamber.
GLP compliance:
no
Test material information:
Composition 1
Species:
other: human
Irritation parameter:
overall irritation score
Remarks:
1
Basis:
mean
Time point:
other: 0
Score:
1
Max. score:
1
Reversibility:
fully reversible within: several minutes
Interpretation of results:
irritating
Remarks:
Migrated information Criteria used for interpretation of results: expert judgment
Executive summary:

16 ppm of cyanogen caused almost immediate eye irritation which faded away several minutes after the end of exposure. 8 ppm of cyanogen caused no eye irritation at all.

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Respiratory irritation

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Additional information

Effects on eye irritation: slightly irritating

Effects on respiratory irritation: irritating

Justification for classification or non-classification

Company observation data and study by McNerney and Schenk show that eye and respiratory tract irritation occurs at levels above ca 10 ppm of cyanogen.