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Registration Dossier
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EC number: 203-052-4 | CAS number: 102-77-2
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation
- Remarks:
- in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: acceptable well-documented study report which meets basic scientific principles
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 982
- Report date:
- 1982
Materials and methods
- Principles of method if other than guideline:
- other: Repeated Insult Patch Test modified Shelanski (4 x 4 Method)
- GLP compliance:
- yes
- Type of study:
- other: Repeated Insult Patch Test modified Shelanski (4 x 4 Method)
Test material
- Reference substance name:
- 2-(morpholinothio)benzothiazole
- EC Number:
- 203-052-4
- EC Name:
- 2-(morpholinothio)benzothiazole
- Cas Number:
- 102-77-2
- Molecular formula:
- C11H12N2OS2
- IUPAC Name:
- 2-(morpholin-4-ylsulfanyl)-1,3-benzothiazole
- Details on test material:
- N-oxydiethylene-benzothiazole sulphenamide, brown granules
Constituent 1
In vivo test system
Test animals
- Species:
- human
- Sex:
- male/female
Study design: in vivo (non-LLNA)
Inductionopen allclose all
- Route:
- epicutaneous, occlusive
- Vehicle:
- petrolatum
- Concentration / amount:
- 75 % in petrolatum
Challengeopen allclose all
- Route:
- epicutaneous, occlusive
- Vehicle:
- petrolatum
- Concentration / amount:
- 75 % in petrolatum
- No. of animals per dose:
- 49 volunteers
Results and discussion
In vivo (non-LLNA)
Resultsopen allclose all
- Reading:
- other: Irritation during induction phase
- Group:
- test chemical
- Dose level:
- 75 %
- No. with + reactions:
- 31
- Total no. in group:
- 49
- Remarks on result:
- other: Reading: other: Irritation during induction phase. Group: test group. Dose level: 75 %. No with. + reactions: 31.0. Total no. in groups: 49.0.
- Reading:
- other: sensitizing during induction phase
- Group:
- test chemical
- Dose level:
- 75 %
- No. with + reactions:
- 24
- Total no. in group:
- 49
- Remarks on result:
- other: Reading: other: sensitizing during induction phase. Group: test group. Dose level: 75 %. No with. + reactions: 24.0. Total no. in groups: 49.0.
Any other information on results incl. tables
Irritation:
The test material elicited irritation in 31/49 individuals.This was well over 50 % of the panelists participating in the study. Minimal or moderate erythema was the extent of irritation in seven (7/49) of these individuals, the picture in the remaining 24 individuals was quite different.
Sensitizing:
During induction phase: 24 individuals (24/49) showed intensive or very intense irritation, consisting of erythema, induration, weeping, and extension beyond the margin of the contact site. The characteristics of these responses were consistent with that of a sensitizing effect.
Applicant's summary and conclusion
- Interpretation of results:
- sensitising
- Remarks:
- Migrated information
- Executive summary:
The test substance (75 % preparation in pet.) induced a allergic response in 24/49 human volunteeres (Monsanto Co.1982).
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