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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin sensitisation

Currently viewing:

Administrative data

Endpoint:
skin sensitisation
Remarks:
in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: acceptable well-documented study report which meets basic scientific principles
Cross-reference
Reason / purpose for cross-reference:
reference to same study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1982
Report date:
1982

Materials and methods

Principles of method if other than guideline:
other: Repeated Insult Patch Test modified Shelanski (4 x 4 Method)
GLP compliance:
yes
Type of study:
other: Repeated Insult Patch Test modified Shelanski (4 x 4 Method)

Test material

Constituent 1
Chemical structure
Reference substance name:
2-(morpholinothio)benzothiazole
EC Number:
203-052-4
EC Name:
2-(morpholinothio)benzothiazole
Cas Number:
102-77-2
Molecular formula:
C11H12N2OS2
IUPAC Name:
2-(morpholin-4-ylsulfanyl)-1,3-benzothiazole
Details on test material:
N-oxydiethylene-benzothiazole sulphenamide, brown granules

In vivo test system

Test animals

Species:
human
Sex:
male/female

Study design: in vivo (non-LLNA)

Inductionopen allclose all
Route:
epicutaneous, occlusive
Vehicle:
petrolatum
Concentration / amount:
75 % in petrolatum
Challengeopen allclose all
Route:
epicutaneous, occlusive
Vehicle:
petrolatum
Concentration / amount:
75 % in petrolatum
No. of animals per dose:
49 volunteers

Results and discussion

In vivo (non-LLNA)

Resultsopen allclose all
Reading:
other: Irritation during induction phase
Group:
test chemical
Dose level:
75 %
No. with + reactions:
31
Total no. in group:
49
Remarks on result:
other: Reading: other: Irritation during induction phase. Group: test group. Dose level: 75 %. No with. + reactions: 31.0. Total no. in groups: 49.0.
Reading:
other: sensitizing during induction phase
Group:
test chemical
Dose level:
75 %
No. with + reactions:
24
Total no. in group:
49
Remarks on result:
other: Reading: other: sensitizing during induction phase. Group: test group. Dose level: 75 %. No with. + reactions: 24.0. Total no. in groups: 49.0.

Any other information on results incl. tables

Irritation:

The test material elicited irritation in 31/49 individuals.This was well over 50 % of the panelists participating in the study. Minimal or moderate erythema was the extent of irritation in seven (7/49) of these individuals, the picture in the remaining 24 individuals was quite different.

Sensitizing:

During induction phase: 24 individuals (24/49) showed intensive or very intense irritation, consisting of erythema, induration, weeping, and extension beyond the margin of the contact site. The characteristics of these responses were consistent with that of a sensitizing effect.

Applicant's summary and conclusion

Interpretation of results:
sensitising
Remarks:
Migrated information
Executive summary:

The test substance (75 % preparation in pet.) induced a allergic response in 24/49 human volunteeres (Monsanto Co.1982).