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EC number: 203-052-4
CAS number: 102-77-2
The metabolic fate of the test article in rats was studied using tracer
techniques. The compound given orally to rats, was rapidly excreted in
the urine and feces. Five urinary metabolites, (2-mercaptobenzothiazole,
its three conjugates mercapturate, glucuronide and sulfate, and 2
-mercaptobenzothiazole disulfide) were confirmed.
2-mercaptobenzothiazole disulfide was also found as a fecal metabolite.
The test compound was partially transformed in the stomach to
2-mercaptobenzothiazole disulfide,which was predominately excreted into
feces. In the liver, the test compound was mainly transformed to
2-mercaptobenzothiazole and its conjugates. The S-glucuronide and
S-sulfate conjugates were predominately excreted into bile.
14C was rapidly absorbed , as indicated blood peak levels at 15 to 30
min after administration and undergo enterohepatic circulation
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